EBK HUMAN ANATOMY & PHYSIOLOGY
1st Edition
ISBN: 9780100659834
Author: AMERMAN
Publisher: YUZU
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Textbook Question
Chapter 2, Problem 4CYR
Explain the difference between an ionic and a covalent bond.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 2 Solutions
EBK HUMAN ANATOMY & PHYSIOLOGY
Ch. 2.1 - Prob. 1QCCh. 2.1 - What are atoms?Ch. 2.1 - How do the three types of subatomic particles...Ch. 2.1 - What is an element?Ch. 2.1 - 4. How are elements arranged in the periodic...Ch. 2.1 - What are isotopes?Ch. 2.1 - Prob. 1AWYLCh. 2.1 - The element lithium has an atomic number of 3 and...Ch. 2.2 - What is a mixture?Ch. 2.2 - 2. How do the three types of mixtures differ?
Ch. 2.2 - Prob. 3QCCh. 2.2 - What is an ionic bond?Ch. 2.2 - 5. How is an ionic bond formed?
Ch. 2.2 - 6. Explain how polar and nonpolar covalent bonds...Ch. 2.2 - What are hydrogen bonds? Why do hydrogen bonds...Ch. 2.2 - Which would be more reactive-an atom of fluorine...Ch. 2.2 - Would a molecule of hydrogen (H2) form hydrogen...Ch. 2.2 - Explain why the molecule Na2 does not exist in...Ch. 2.3 - Prob. 1QCCh. 2.3 - Prob. 2QCCh. 2.3 - How do endergonic and exergonic reactions differ?Ch. 2.3 - Prob. 4QCCh. 2.3 - What factors can influence the rate of a chemical...Ch. 2.3 - 6. What is an enzyme, and what does an enzyme do?
Ch. 2.3 - Prob. 1AWYLCh. 2.3 - Explain why most biological molecules are stable...Ch. 2.3 - 3. Many naturally occurring poisons function by...Ch. 2.4 - What are four properties of water that make it a...Ch. 2.4 - 2. Which molecules are likely to be hydrophilic?...Ch. 2.4 - 3. Define the terms acid and base.
Ch. 2.4 - What is the pH scale? Which pH values are...Ch. 2.4 - What is the effect of a buffer on a solution?Ch. 2.4 - What is a salt?Ch. 2.4 - 7. What does an electrolyte do in a solution?
Ch. 2.4 - Explain how the water surrounding a fetus in the...Ch. 2.4 - Prob. 2AWYLCh. 2.5 - 1. How do polymers and monomers differ?
Ch. 2.5 - 2.3. How do monosaccharides, disaccharides, and...Ch. 2.5 - 2. How do monosaccharides, disaccharides, and...Ch. 2.5 - How are two monosaccharides linked to form a...Ch. 2.5 - Prob. 5QCCh. 2.5 - 5. How do phospholipids and triglycerides differ?
Ch. 2.5 - What are steroids?Ch. 2.5 - Prob. 8QCCh. 2.5 - How are amino acids linked to form peptides and...Ch. 2.5 - What are the four levels of structural...Ch. 2.5 - 10. What are the components and roles of ATP?
Ch. 2.5 - 11. How do DNA and RNA differ?
Ch. 2.5 - 11. What are the three components of a...Ch. 2.5 - Which molecule would be the most soluble in water:...Ch. 2.5 - In Module 2.3, you learned that increasing...Ch. 2.5 - 3. How could a defect in a gene lead to a...Ch. 2 - Prob. 1CYRCh. 2 - Fill in the blanks: Isotopes are atoms with the...Ch. 2 - 3. Which of the following statements correctly...Ch. 2 - 4. Explain the difference between an ionic and a...Ch. 2 - Identify each of the following molecules or...Ch. 2 - What are hydrogen bonds, and how do they form?Ch. 2 - Prob. 7CYRCh. 2 - Prob. 8CYRCh. 2 - Which of the following would not result in an...Ch. 2 - 10. An enzyme is a:
a. biological catalyst that...Ch. 2 - Prob. 11CYRCh. 2 - With respect to their solubility in water,...Ch. 2 - Mark the following statements as true or false. If...Ch. 2 - A salt is: a. a metal cation bonded to a nonmetal...Ch. 2 - 15. Compare and contrast the structures of...Ch. 2 - 16. Mark the following statements as true or...Ch. 2 - 17. Why is it important for a protein to maintain...Ch. 2 - Which of the following is not part of a...Ch. 2 - 19. Mark the following properties as belonging to...Ch. 2 - Which of the following statements is/are true...Ch. 2 - 1. In certain types of radioactive decay, the...Ch. 2 - Considering that water is a main component of the...Ch. 2 - 3. Explain why monosaccharides are polar and fatty...Ch. 2 - 1. The polysaccharide cellulose is not digestible...Ch. 2 - Some claim that the pH of your blood can be...Ch. 2 - Prob. 3AYKCh. 2 - Prob. 5AYKCh. 2 - You have just dropped some phospholipids into...
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