ANATOMY AND PHYSIOLOGY
17th Edition
ISBN: 9781630180928
Author: OpenStax
Publisher: OPENSTAX C
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Chapter 2, Problem 30RQ
In DNA,
- beta chain
- pleated sheet
- alpha helix
- double helix
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 2 Solutions
ANATOMY AND PHYSIOLOGY
Ch. 2 - Visit this website...Ch. 2 - Visit this website...Ch. 2 - Watch this video...Ch. 2 - Together, just four elements make up more than 95...Ch. 2 - The smallest unit of an element that still retains...Ch. 2 - The characteristic that gives an element its...Ch. 2 - On the periodic table of the elements, mercury...Ch. 2 - Nitrogen has an atomic number of seven. How many...Ch. 2 - Which of the following is a molecule, but not a...Ch. 2 - A molecule of ammonia contains one atom of...
Ch. 2 - When an atom donates an electron to another atom,...Ch. 2 - A substance formed of crystals of equal numbers of...Ch. 2 - Which of the following statements about chemical...Ch. 2 - The energy stored in a foot of snow on a steep...Ch. 2 - The bonding of calcium, phosphorus, and other...Ch. 2 - ABA+B is a general notation for a(n) ________...Ch. 2 - __________ reactions release energy. Catabolic...Ch. 2 - Which of the following combinations of atoms is...Ch. 2 - Chewing a bite of bread mixes it with saliva and...Ch. 2 - CH4 is methane. This compound is ________....Ch. 2 - Which of the following is most likely to be found...Ch. 2 - Jenny mixes up a batch of pancake batter, then...Ch. 2 - A substance dissociates into K+ and Cl- in...Ch. 2 - Ty is three years old and as a result of a stomach...Ch. 2 - C6H12O6 is the chemical formula for a ________....Ch. 2 - What organic compound do brain cells primarily...Ch. 2 - Which of the following is a functional group that...Ch. 2 - A pentose sugar is a part of the monomer used to...Ch. 2 - A phospholipid ________. has both polar and...Ch. 2 - In DNA, nucleotide bonding forms a compound with a...Ch. 2 - Uracil ________. contains nitrogen is a pyrimidine...Ch. 2 - The ability of an enzymes active sites to bind...Ch. 2 - The most abundant elements In the foods and...Ch. 2 - Oxygen, whose atomic number is eight, has three...Ch. 2 - Magnesium is an important element in the human...Ch. 2 - Explain why CH4 is one of the most common...Ch. 2 - In a hurry one day, you merely rinse your lunch...Ch. 2 - Could two atoms of oxygen engage in ionic bonding?...Ch. 2 - AB+CDAD+BE Is this a legitimate example of an...Ch. 2 - When you do a load of laundry, why do you not just...Ch. 2 - The pH of lemon juice is 2, and the pH of orange...Ch. 2 - During a party, Eli loses a bet and is forced to...Ch. 2 - If the disaccharide maltose is formed from two...Ch. 2 - Once dietary fats are digested and absorbed, why...
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