Concepts of Genetics Plus Mastering Genetics with Pearson eText -- Access Card Package (12th Edition) (What's New in Genetics)
12th Edition
ISBN: 9780134811390
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 2, Problem 25ESP
In mitosis, what chromatid combination(s) will be present during metaphase? What combination(s) will be present at each pole at the completion of anaphase?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 2 Solutions
Concepts of Genetics Plus Mastering Genetics with Pearson eText -- Access Card Package (12th Edition) (What's New in Genetics)
Ch. 2 - With the initial appearance of the feature we call...Ch. 2 - An organism has a diploid number of 16 in a...Ch. 2 - Examine Figure 2.12, which shows oogenesis in...Ch. 2 - Over a period of two years, a man in his early 20s...Ch. 2 - Over a period of two years, a man in his early 20s...Ch. 2 - Over a period of two years, a man in his early 20s...Ch. 2 - In this chapter, we focused on how chromosomes are...Ch. 2 - Review the Chapter Concepts list on page 14. All...Ch. 2 - What role do the following cellular components...Ch. 2 - Discuss the concepts of homologous chromosomes,...
Ch. 2 - If two chromosomes of a species are the same...Ch. 2 - Describe the events that characterize each stage...Ch. 2 - How are chromosomes named on the basis of their...Ch. 2 - Contrast telophase in plant and animal mitosis.Ch. 2 - Describe the phases of the cell cycle and the...Ch. 2 - Define and discuss these terms: (a) synapsis, (b)...Ch. 2 - Contrast the genetic content and the origin of...Ch. 2 - Given the end results of the two types of...Ch. 2 - Contrast spermatogenesis and oogenesis. What is...Ch. 2 - Explain why meiosis leads to significant genetic...Ch. 2 - A diploid cell contains three pairs of homologous...Ch. 2 - Considering Problem 15, predict the number of...Ch. 2 - During oogenesis in an animal species with a...Ch. 2 - What is the probability that, in an organism with...Ch. 2 - The nuclear DNA content of a single sperm cell in...Ch. 2 - Describe the role of meiosis in the life cycle of...Ch. 2 - Contrast the chromatin fiber with the mitotic...Ch. 2 - Describe the folded-fiber model of the mitotic...Ch. 2 - Prob. 23PDQCh. 2 - If one follows 50 primary oocytes in an animal...Ch. 2 - In mitosis, what chromatid combination(s) will be...Ch. 2 - During meiosis I, assuming no crossing over, what...Ch. 2 - Are there any possible combinations present during...Ch. 2 - Draw all possible combinations of chromatids...Ch. 2 - Assume that during meiosis I none of the C...Ch. 2 - Assume that each gamete resulting from Problem 29...Ch. 2 - A species of cereal rye (Secale cereale) has a...Ch. 2 - An interesting procedure has been applied for...Ch. 2 - Assume that you were examining a first polar body...Ch. 2 - Kuliev and Verlinsky (2004) state that there was a...
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- Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The misinformation website and link What misinformation is being provided in the other website and how did you determine it was not credible?arrow_forward1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.arrow_forward2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…arrow_forward
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