The following problem can be comprehended by the concept of medial lethal dose (LD 50 ). Concept introduction: The LD 50 is the measure of lethal dose of a substance. It is the amount of substance that is required to kill half of the test population. A lower value of LD 50 indicates increased toxicity. Usually, it is calculated by testing on laboratory animals (usually rodents). It is usually expressed as milligram of substance per kilogram of body weight. It helps in comparing the toxicities of different substances. Given: We are given the LD 50 of caffeine (192 mg/kg) and we are asked to find out the quantity of each of the following that must be ingested to provide the LD 50 for caffeine. (a) Cups of coffee if one cup is 12 fl oz and there is 100 mg of caffeine per 6 fl oz of drip-brewed coffee (b) Cans of cola if one can contains 50 mg of caffeine (c) Tablet of No. DOz if of tablet contains 100 mg of caffeine

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Chapter 2, Problem 2.105CQ

Interpretation Introduction

Interpretation: The following problem can be comprehended by the concept of medial lethal dose (LD₅₀).

Concept introduction: The LD₅₀ is the measure of lethal dose of a substance. It is the amount of substance that is required to kill half of the test population. A lower value of LD₅₀ indicates increased toxicity. Usually, it is calculated by testing on laboratory animals (usually rodents). It is usually expressed as milligram of substance per kilogram of body weight. It helps in comparing the toxicities of different substances.

Given: We are given the LD₅₀ of caffeine (192 mg/kg) and we are asked to find out the quantity of each of the following that must be ingested to provide the LD₅₀ for caffeine.

(a) Cups of coffee if one cup is 12 fl oz and there is 100 mg of caffeine per 6 fl oz of drip-brewed coffee

(b) Cans of cola if one can contains 50 mg of caffeine

(c) Tablet of No. DOz if of tablet contains 100 mg of caffeine

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