Cardiopulmonary Anatomy & Physiology
Cardiopulmonary Anatomy & Physiology
7th Edition
ISBN: 9781337794909
Author: Des Jardins, Terry.
Publisher: Cengage Learning,
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Chapter 2, Problem 11RQ
Summary Introduction

Introduction:

Alveolar pressure is the pressure inside the alveoli of the lungs and it plays a key role during inspiration. The alveolar pressure decreases during inspiration due to the expansion of the lungs to a value lower than atmospheric pressure. This results in the movement of air into the lungs. The pleural pressure refers to the pressure within the pleural cavity, which is also slightly less than the atmospheric pressure and is termed as negative pressure. The alveolar pressure of the lungs is always greater than the pleural pressure in case of normal lungs, which is also necessary for maintaining the inflated state of the lungs.

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
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