
Concept explainers
To determine:
- The main clinical strategy in preventing gas gangrene.
- Why it works.
Introduction:
Gas gangrene is a clostridial tissue infection in which the bacterial cells growing in the tissue produce gas and necrotizing toxins. It occurs in surgical incisions, puncture wounds, compound fractures and internal injuries like septic abortions.

Explanation of Solution
The prevention of gas gangrene involves thorough cleaning of the wound and surgical repair of deep wounds, fractures and infected incisions. Any diseases tissue must be removed through debridement.
The reason for the effectiveness of these preventive measures is the fact that clostridia are not highly invasive bacteria. They are able to grow only if the wound environment becomes anaerobic and conducive to their growth. This happens when the there is reduced blood flow to the tissue (which reduces oxygen supply) and other bacteria grow in the wound (which use up and further reduce the oxygen). By cleaning the wound growth of other bacteria is prevented. Debridement remove dead tissue that have lost blood supply.
The prevention of gas gangrene involves thorough cleaning of the wound and debridement. These measures work because they prevent the wound environment from becoming anaerobic and supporting the growth of clostridia.
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Chapter 19 Solutions
Foundations in Microbiology
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