ANAT.+PHYS.LAB MANUAL-W/ACCESS >CUSTOM<
9th Edition
ISBN: 9781265357948
Author: SALADIN
Publisher: MCG CUSTOM
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Chapter 19.6, Problem 17AYLO
Why stroke volume may be unusually high and resting heart rate unusually low in people who have sustained programs of endurance exercise
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 19 Solutions
ANAT.+PHYS.LAB MANUAL-W/ACCESS >CUSTOM<
Ch. 19.1 - Prob. 1AYLOCh. 19.1 - Names of the great vessels directly connected to...Ch. 19.1 - Prob. 3AYLOCh. 19.1 - Prob. 4AYLOCh. 19.2 - Prob. 3BYGOCh. 19.2 - Prob. 1AYLOCh. 19.2 - Relative thickness of the myocardium in different...Ch. 19.2 - Structure and function of the fibrous skeleton of...Ch. 19.2 - Prob. 4AYLOCh. 19.2 - Names and synonyms for all four valves of the...
Ch. 19.2 - Prob. 6AYLOCh. 19.2 - Prob. 7AYLOCh. 19.2 - Prob. 8AYLOCh. 19.2 - Prob. 9AYLOCh. 19.2 - Prob. 10AYLOCh. 19.2 - Anatomy of the major veins that drain the...Ch. 19.3 - Prob. 1AYLOCh. 19.3 - Prob. 2AYLOCh. 19.3 - Components, of the cardiac conduction system and...Ch. 19.4 - Prob. 1AYLOCh. 19.4 - Prob. 2AYLOCh. 19.4 - The mechanism that causes cells of the SA node to...Ch. 19.4 - The spread of excitation through the atria, AV...Ch. 19.4 - Prob. 5AYLOCh. 19.4 - Prob. 6AYLOCh. 19.4 - Prob. 7AYLOCh. 19.5 - Prob. 1AYLOCh. 19.5 - Prob. 2AYLOCh. 19.5 - Prob. 3AYLOCh. 19.5 - Prob. 4AYLOCh. 19.5 - In each phase of the cardiac cycle, which chambers...Ch. 19.5 - The typical duration, in seconds, of atrial...Ch. 19.5 - Prob. 7AYLOCh. 19.5 - Prob. 8AYLOCh. 19.6 - Prob. 29BYGOCh. 19.6 - Prob. 30BYGOCh. 19.6 - The definition of cardiac output (CO); how it can...Ch. 19.6 - Prob. 2AYLOCh. 19.6 - Prob. 3AYLOCh. 19.6 - Prob. 4AYLOCh. 19.6 - Prob. 5AYLOCh. 19.6 - Mechanisms by which sympathetic and...Ch. 19.6 - Prob. 7AYLOCh. 19.6 - Prob. 8AYLOCh. 19.6 - Mechanisms by which epinephrine and...Ch. 19.6 - Prob. 10AYLOCh. 19.6 - Prob. 11AYLOCh. 19.6 - Prob. 12AYLOCh. 19.6 - Prob. 13AYLOCh. 19.6 - Prob. 14AYLOCh. 19.6 - Conditions that increase afterload: the effect of...Ch. 19.6 - Prob. 16AYLOCh. 19.6 - Why stroke volume may be unusually high and...Ch. 19.6 - Prob. 18AYLOCh. 19.6 - Prob. 19AYLOCh. 19.6 - Prob. 20AYLOCh. 19.6 - Prob. 21AYLOCh. 19 - The cardiac conduction system includes all of the...Ch. 19 - Prob. 2TYRCh. 19 - Assume that one ventricle of a childs heart has...Ch. 19 - Prob. 4TYRCh. 19 - Prob. 5TYRCh. 19 - Prob. 6TYRCh. 19 - The atria contract during a. the first heart...Ch. 19 - Prob. 8TYRCh. 19 - Prob. 9TYRCh. 19 - Prob. 10TYRCh. 19 - The contraction of any heart chamber is called and...Ch. 19 - Prob. 12TYRCh. 19 - The circumflex artery travels in a groove called...Ch. 19 - Prob. 14TYRCh. 19 - Electrical signals pass quickly from one...Ch. 19 - Repolarization of the ventricles produces the of...Ch. 19 - Prob. 17TYRCh. 19 - Prob. 18TYRCh. 19 - Blood in the heart chambers is separated from the...Ch. 19 - The Frank-Starling law of the heart explains why...Ch. 19 - atrio-Ch. 19 - brady-Ch. 19 - Prob. 3BYMVCh. 19 - Prob. 4BYMVCh. 19 - lun-Ch. 19 - Prob. 6BYMVCh. 19 - Prob. 7BYMVCh. 19 - Prob. 8BYMVCh. 19 - Prob. 9BYMVCh. 19 - Prob. 10BYMVCh. 19 - Prob. 1WWTSCh. 19 - One-way valves prevent atrial systole from driving...Ch. 19 - Prob. 3WWTSCh. 19 - Prob. 4WWTSCh. 19 - Prob. 5WWTSCh. 19 - Prob. 6WWTSCh. 19 - If all nerves to the heart were severed, the heart...Ch. 19 - If the two pulmonary arteries were clamped shut,...Ch. 19 - Unlike skeletal muscle, cardiac muscle cells do...Ch. 19 - An electrocardiogram is a tracing of the action...Ch. 19 - Prob. 1TYCCh. 19 - Prob. 2TYCCh. 19 - Becky, age 2, was born with a hole in her...Ch. 19 - Prob. 4TYCCh. 19 - Prob. 5TYC
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