ANAT.+PHYS.LAB MANUAL-W/ACCESS >CUSTOM<
9th Edition
ISBN: 9781265357948
Author: SALADIN
Publisher: MCG CUSTOM
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Chapter 19.6, Problem 16AYLO
Summary Introduction
To discuss:
Why the cardiac output increases at the outset of exercise and another factor that increases output as exercise continues.
Introduction:
Cardiac output is a term defined as the number of heartbeat per minute and the amount of blood pumped out by the ventricles for every beat. It is expressed by the formula of
Cardiac output = Heart rate (HR) x Stroke volume (SV)
Cardiac output differs from individual to individual and age pattern.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 19 Solutions
ANAT.+PHYS.LAB MANUAL-W/ACCESS >CUSTOM<
Ch. 19.1 - Prob. 1AYLOCh. 19.1 - Names of the great vessels directly connected to...Ch. 19.1 - Prob. 3AYLOCh. 19.1 - Prob. 4AYLOCh. 19.2 - Prob. 3BYGOCh. 19.2 - Prob. 1AYLOCh. 19.2 - Relative thickness of the myocardium in different...Ch. 19.2 - Structure and function of the fibrous skeleton of...Ch. 19.2 - Prob. 4AYLOCh. 19.2 - Names and synonyms for all four valves of the...
Ch. 19.2 - Prob. 6AYLOCh. 19.2 - Prob. 7AYLOCh. 19.2 - Prob. 8AYLOCh. 19.2 - Prob. 9AYLOCh. 19.2 - Prob. 10AYLOCh. 19.2 - Anatomy of the major veins that drain the...Ch. 19.3 - Prob. 1AYLOCh. 19.3 - Prob. 2AYLOCh. 19.3 - Components, of the cardiac conduction system and...Ch. 19.4 - Prob. 1AYLOCh. 19.4 - Prob. 2AYLOCh. 19.4 - The mechanism that causes cells of the SA node to...Ch. 19.4 - The spread of excitation through the atria, AV...Ch. 19.4 - Prob. 5AYLOCh. 19.4 - Prob. 6AYLOCh. 19.4 - Prob. 7AYLOCh. 19.5 - Prob. 1AYLOCh. 19.5 - Prob. 2AYLOCh. 19.5 - Prob. 3AYLOCh. 19.5 - Prob. 4AYLOCh. 19.5 - In each phase of the cardiac cycle, which chambers...Ch. 19.5 - The typical duration, in seconds, of atrial...Ch. 19.5 - Prob. 7AYLOCh. 19.5 - Prob. 8AYLOCh. 19.6 - Prob. 29BYGOCh. 19.6 - Prob. 30BYGOCh. 19.6 - The definition of cardiac output (CO); how it can...Ch. 19.6 - Prob. 2AYLOCh. 19.6 - Prob. 3AYLOCh. 19.6 - Prob. 4AYLOCh. 19.6 - Prob. 5AYLOCh. 19.6 - Mechanisms by which sympathetic and...Ch. 19.6 - Prob. 7AYLOCh. 19.6 - Prob. 8AYLOCh. 19.6 - Mechanisms by which epinephrine and...Ch. 19.6 - Prob. 10AYLOCh. 19.6 - Prob. 11AYLOCh. 19.6 - Prob. 12AYLOCh. 19.6 - Prob. 13AYLOCh. 19.6 - Prob. 14AYLOCh. 19.6 - Conditions that increase afterload: the effect of...Ch. 19.6 - Prob. 16AYLOCh. 19.6 - Why stroke volume may be unusually high and...Ch. 19.6 - Prob. 18AYLOCh. 19.6 - Prob. 19AYLOCh. 19.6 - Prob. 20AYLOCh. 19.6 - Prob. 21AYLOCh. 19 - The cardiac conduction system includes all of the...Ch. 19 - Prob. 2TYRCh. 19 - Assume that one ventricle of a childs heart has...Ch. 19 - Prob. 4TYRCh. 19 - Prob. 5TYRCh. 19 - Prob. 6TYRCh. 19 - The atria contract during a. the first heart...Ch. 19 - Prob. 8TYRCh. 19 - Prob. 9TYRCh. 19 - Prob. 10TYRCh. 19 - The contraction of any heart chamber is called and...Ch. 19 - Prob. 12TYRCh. 19 - The circumflex artery travels in a groove called...Ch. 19 - Prob. 14TYRCh. 19 - Electrical signals pass quickly from one...Ch. 19 - Repolarization of the ventricles produces the of...Ch. 19 - Prob. 17TYRCh. 19 - Prob. 18TYRCh. 19 - Blood in the heart chambers is separated from the...Ch. 19 - The Frank-Starling law of the heart explains why...Ch. 19 - atrio-Ch. 19 - brady-Ch. 19 - Prob. 3BYMVCh. 19 - Prob. 4BYMVCh. 19 - lun-Ch. 19 - Prob. 6BYMVCh. 19 - Prob. 7BYMVCh. 19 - Prob. 8BYMVCh. 19 - Prob. 9BYMVCh. 19 - Prob. 10BYMVCh. 19 - Prob. 1WWTSCh. 19 - One-way valves prevent atrial systole from driving...Ch. 19 - Prob. 3WWTSCh. 19 - Prob. 4WWTSCh. 19 - Prob. 5WWTSCh. 19 - Prob. 6WWTSCh. 19 - If all nerves to the heart were severed, the heart...Ch. 19 - If the two pulmonary arteries were clamped shut,...Ch. 19 - Unlike skeletal muscle, cardiac muscle cells do...Ch. 19 - An electrocardiogram is a tracing of the action...Ch. 19 - Prob. 1TYCCh. 19 - Prob. 2TYCCh. 19 - Becky, age 2, was born with a hole in her...Ch. 19 - Prob. 4TYCCh. 19 - Prob. 5TYC
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