Human Biology
16th Edition
ISBN: 9781260482799
Author: Mader, Sylvia
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 19.4, Problem 2CYP
Explain how meiosis reduces the likelihood that gametes will have the same combination of chromosomes and genes.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 19 Solutions
Human Biology
Ch. 19.1 - Distinguish between a chromosome and chromatin.Ch. 19.1 - Prob. 2LOCh. 19.1 - Prob. 3LOCh. 19.1 - Prob. 1CYPCh. 19.1 - Prob. 2CYPCh. 19.1 - Prob. 3CYPCh. 19.2 - Prob. 1LOCh. 19.2 - Prob. 2LOCh. 19.2 - Prob. 3LOCh. 19.2 - Describe the cell cycle, and list the locations of...
Ch. 19.2 - Prob. 2CYPCh. 19.2 - Prob. 3CYPCh. 19.2 - Summarize why external controls may be necessary...Ch. 19.3 - Prob. 1LOCh. 19.3 - Prob. 2LOCh. 19.3 - Prob. 3LOCh. 19.3 - Prob. 1CYPCh. 19.3 - Prob. 2CYPCh. 19.3 - Prob. 3CYPCh. 19.4 - Prob. 1LOCh. 19.4 - Prob. 2LOCh. 19.4 - Prob. 3LOCh. 19.4 - Prob. 1CYPCh. 19.4 - Explain how meiosis reduces the likelihood that...Ch. 19.4 - Prob. 3CYPCh. 19.4 - Compare and contrast the stages of oogenesis and...Ch. 19.5 - Prob. 1LOCh. 19.5 - Prob. 2LOCh. 19.5 - List the similarities and differences between...Ch. 19.5 - Prob. 2CYPCh. 19.5 - Prob. 3CYPCh. 19.6 - Prob. 1LOCh. 19.6 - Describe the causes and consequences of trisomy...Ch. 19.6 - Prob. 3LOCh. 19.6 - 4. Describe the effects of deletions,...Ch. 19.6 - Prob. 1BTSCh. 19.6 - Prob. 2BTSCh. 19.6 - Prob. 1CYPCh. 19.6 - Prob. 2CYPCh. 19.6 - Prob. 3CYPCh. 19.6 - Prob. 4CYPCh. 19 - Prob. 1ACh. 19 - 2. Which of the following is/are produced by the...Ch. 19 - 3. Label the drawing of the cell cycle: then list...Ch. 19 - 4. At which of the following checkpoints is the...Ch. 19 - ...Ch. 19 - ...Ch. 19 - a. metaphase
b....Ch. 19 - ...Ch. 19 - metaphase
prornetaphase
telophase
prophase c....Ch. 19 - 10. If a parent cell has a diploid number of 18...Ch. 19 - 11. If a parent cell has 22 chromosomes. the...Ch. 19 - 12. Crossing-over occurs between
sister chromatids...Ch. 19 - 13. Which of these helps provide genetic...Ch. 19 - 14. Polar bodies are produced during
DNA...Ch. 19 - 15. The pairing of homologous chromosomes occurs...Ch. 19 - 16. Sister chromatids separate during anaphase of...Ch. 19 - 17. Monosomy or trisomy occurs because...Ch. 19 - 18. A person with Klinefelter syndrome is and...Ch. 19 - Prob. 1TCCh. 19 - Prob. 2TCCh. 19 - Prob. 3TCCh. 19 - Prob. 4TC
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