Human Anatomy
9th Edition
ISBN: 9780135168059
Author: Marieb, Elaine Nicpon, Brady, Patricia, Mallatt, Jon
Publisher: Pearson Education, Inc.,
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Chapter 19, Problem 9CYU
What is the significance of the gap junctions in the intercalated discs?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 19 Solutions
Human Anatomy
Ch. 19 - Prob. 1CYUCh. 19 - Prob. 2CYUCh. 19 - What is another name for the epicardium?Ch. 19 - Identify the heart chamber or chambers that...Ch. 19 - Prob. 5CYUCh. 19 - Prob. 6CYUCh. 19 - During ventricular systole, are the AV valves open...Ch. 19 - Differentiate a stenotic valve from an incompetent...Ch. 19 - What is the significance of the gap junctions in...Ch. 19 - What is the pacemaker of the heart, and where is...
Ch. 19 - Prob. 11CYUCh. 19 - Prob. 12CYUCh. 19 - Prob. 13CYUCh. 19 - How would incomplete formation of the...Ch. 19 - Which chamber of the heart is formed from the...Ch. 19 - What is the single most important factor for...Ch. 19 - The most external part of the pericardium is the...Ch. 19 - Prob. 2RQCh. 19 - How many cusps does the right atrioventricular...Ch. 19 - Prob. 4RQCh. 19 - Prob. 5RQCh. 19 - Prob. 6RQCh. 19 - Prob. 7RQCh. 19 - Prob. 8RQCh. 19 - Prob. 9RQCh. 19 - Which layer of the heart wall is the thickest? (a)...Ch. 19 - The inferior left corner of the heart is located...Ch. 19 - Ben was annoyed when his lab partner insisted that...Ch. 19 - Describe the location of the heart within the...Ch. 19 - Trace a drop of blood through all the heart...Ch. 19 - Prob. 15RQCh. 19 - Sketch the heart and draw all the coronary vessels...Ch. 19 - Prob. 17RQCh. 19 - Prob. 18RQCh. 19 - Make a drawing of the adult heart and the...Ch. 19 - How do the right and left ventricles differ...Ch. 19 - Which is more resistant to fatigue, cardiac muscle...Ch. 19 - Describe the structure and function of an...Ch. 19 - Compare and contrast the structure of cardiac...Ch. 19 - Classify the three congenital heart...Ch. 19 - Prob. 2CRCAQCh. 19 - Prob. 3CRCAQCh. 19 - After a man was stabbed in the chest, his face...Ch. 19 - A heroin addict felt tired, weak, and feverish....Ch. 19 - Another patient had an abnormal heart sound that...Ch. 19 - Prob. 7CRCAQCh. 19 - During a lethal heart attack, a blood. clot lodges...Ch. 19 - Prob. 9CRCAQ
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