Campbell Biology in Focus; Modified Mastering Biology with Pearson eText -- ValuePack Access Card -- for Campbell Biology in Focus (2nd Edition)
2nd Edition
ISBN: 9780134433776
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman
Publisher: PEARSON
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Chapter 19, Problem 7TYU
FOCUS ON EVOLUTION
Explain why anatomical and molecular features often fit a similar nested patter. In addition, describe a process that can cause this not to be the case.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 19 Solutions
Campbell Biology in Focus; Modified Mastering Biology with Pearson eText -- ValuePack Access Card -- for Campbell Biology in Focus (2nd Edition)
Ch. 19.1 - How did Huttons and Lyells ideas influence Darwins...Ch. 19.1 - MAKE CONNECTIONS Scientific hypotheses must be...Ch. 19.2 - How does the concept of descent with modification...Ch. 19.2 - Prob. 2CCCh. 19.2 - MAKE CONNECTIONS Review the relationship between...Ch. 19.3 - Explain how the following statement is inaccurate:...Ch. 19.3 - How does evolution account for (a) the similar...Ch. 19.3 - WHAT IF? Fossils show that dinosaurs originated...Ch. 19 - Which of the following is not an observation or...Ch. 19 - Which of the following observations helped Darwin...
Ch. 19 - Prob. 3TYUCh. 19 - The upper forelimbs of humans and bats have fairly...Ch. 19 - DNA sequences In many human genes are very similar...Ch. 19 - SCIENTIFIC INQUIRY DRAW IT Mosquitoes resistant to...Ch. 19 - FOCUS ON EVOLUTION Explain why anatomical and...Ch. 19 - FOCUS ON INTERACTIONS Write a short essay (about...Ch. 19 - SYNTHESIZE YOUR KNOWLEDGE This honeypot ant (genus...
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