The probability that the children carry the sickle-cell trait and are sickle-cell anemic. Introduction: Homozygous condition is when the same allele of a gene is present on both the homologous chromosomes either dominant or recessive. Heterozygous condition is where different alleles of the gene are present on both the homologous chromosomes where one is dominant and the other is recessive. Sickle-cell anemia occurs due to the homozygous recessive allele that changes the phenotype of the erythrocytes from biconcave to sickle-shaped.

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Chapter 19, Problem 7CT

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To explain: The probability that the children carry the sickle-cell trait and are sickle-cell anemic.

Introduction: Homozygous condition is when the same allele of a gene is present on both the homologous chromosomes either dominant or recessive. Heterozygous condition is where different alleles of the gene are present on both the homologous chromosomes where one is dominant and the other is recessive. Sickle-cell anemia occurs due to the homozygous recessive allele that changes the phenotype of the erythrocytes from biconcave to sickle-shaped.

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Suppose a woman who is a carrier of sickle-cell trait (making her a heterozygote) has children with a man who is totally healthy and does not carry the gene for sickle-cell trait at all. Which one of the following is true about their potential children? (Draw a Punnett square on scratch paper if it helps you.) A) None of their children will have sickle-cell disease. B) All of their children will have sickle-cell disease. C) All of the couple's children would be heterozygous carriers like the mother.

Sickle cell anemia is caused by an individual carrying two recessive copies of the hemoglobin gene (hemoglobin gene is labeled Hb, and the recessive version is Hbs). Thus, to have sickle cell anemia, a person must have the genotype HbSHbS. A person that is HbAHbA carries two copies of the normal hemoglobin gene and does not have sickle cell anemia. A person that is heterozygous (HbAHbS) produces enough normal hemoglobin to not have sickle cell anemia but is also resistant to malaria. People that are heterozygous are called “carriers” because they carry the recessive allele but do not express the recessive phenotype. a. A couple are both resistant to malaria but do not have sickle cell anemia. Draw a Punnett square to represent this cross. b. What is the probability that the couple has three children where one child does not have a recessive allele, one child is resistant to malaria and does not have sickle cell anemia, and one child has sickle cell anemia?

Given the information regarding sickle cell anemia, if two carriers were to have children, what would be the genotypes and phenotypes of their children? Would any of the children show symptoms of the disease?