HUMAN PHYSIOLOGY: AN INTEG ACCESS C
HUMAN PHYSIOLOGY: AN INTEG ACCESS C
8th Edition
ISBN: 9780134714837
Author: Silverthorn
Publisher: PEARSON
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Chapter 19, Problem 21RQ

Draw a section of renal tubule epithelium showing three cells joined by cell junctions. Label the apical and basolateral membranes, the tubule lumen, and the extracellular fluid. Use the following written description of proximal tubule processes to draw a model cell.

The proximal tubule cells contain carbonic anhydrase, which promotes the conversion of CO2 and water H+ and HCO3. Sodium is reabsorbed by an apical Na+-H+ antiporter and a basolateral Na+-K+-ATPase. Chloride is passively reabsorbed by movement through the paracellular pathway. Bicarbonate produced in the cytoplasm leaves the cell on a basolateral Na+-HCO3 symporter.

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Imagine that you are a clinical geneticist. Your colleague is an oncologist who wants your help explaining the basics of genetics to their patient, who will be undergoing genetic testing in the coming weeks for possible acute myeloid leukemia (AML) induced by the radiation she had several years ago for breast cancer. Write a 1,050- to 1,225-word memo to your colleague. Include the following in your memo: An explanation of the molecular structure of DNA and RNA, highlighting both similarities and differences  A description of the processes of transcription and translation An explanation of the differences between leading and lagging strands and how the DNA is replicated in each strand Reponses to the following common questions patients might ask about this type of genetic testing and genetic disorder: Does AML run in families? What genes are tested for?
Respond to the following in a minimum of 175 words: What are some potential consequences that could result if the processes of replication, transcription, and translation don’t function correctly? Provide an example of how you might explain these consequences in terms that patients might understand.

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HUMAN PHYSIOLOGY: AN INTEG ACCESS C

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