Interpretation:
The synthesis of tranquilizer volnoctamide has to be given using diethyl malonate as the source of the carboxamide group.
Concept Introduction:
Acid chlorides are most often prepared by treating a
Reaction of acid chloride with ammonia or
The reaction of acid chlorides with ammonia and primary and secondary amines will yield amide.
The nucleophilic addition of ammonia or amine to the carbonyl carbon occurs which is followed by a proton transfer forming an addition intermediate that will eliminate chloride and lose a proton to give the amide compound.

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Chapter 19 Solutions
OWL V2 with MindTap Reader and Student Solutions Manual eBook for Brown/Iverson/Anslyn/Foote's Organic Chemistry, 8th Edition
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