Foundations in Microbiology
10th Edition
ISBN: 9781259705212
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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Chapter 18.L2, Problem 1CT
You have been handed the problem of diagnosing gonorrhea from a single test. Which one will you choose and why?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 18 Solutions
Foundations in Microbiology
Ch. 18.1 - Prob. 1ELOCh. 18.1 - Describe the ability of S. aureus to withstand...Ch. 18.1 - Prob. 3ELOCh. 18.1 - Summarize the cutaneous, systemic, and toxigenic...Ch. 18.1 - Prob. 5ELOCh. 18.1 - Explain strategies used to prevent and treat...Ch. 18.1 - Prob. 1CYPCh. 18.1 - Discuss why food intoxication in salty foods, such...Ch. 18.1 - Explain how unbroken skin, the phagocytic action...Ch. 18.1 - List the strategies commonly used to prevent and...
Ch. 18.1 - Explain the meanings of the acronyms MRSA, VRE,...Ch. 18.2 - Name the most important human pathogens in the...Ch. 18.2 - Summarize the virulence factors of S. pyogenes, as...Ch. 18.2 - Prob. 9ELOCh. 18.2 - Explain strategies used to prevent and treat...Ch. 18.2 - Relate the pathogenesis and epidemiology of S....Ch. 18.2 - List the clinically significant pathogens in the...Ch. 18.2 - Describe the immediate effects and long-term...Ch. 18.2 - Prob. 8CYPCh. 18.2 - Differentiate between pneumococcal disease...Ch. 18.3 - Name the most important human pathogens in the...Ch. 18.3 - Compare the differences in pathologies of N....Ch. 18.3 - Summarize the pathogenesis and epidemiology of N....Ch. 18.3 - Recall the medically important genera, besides...Ch. 18.3 - Describe the epidemiology and pathology of N....Ch. 18.3 - List the short-term and long-term consequences of...Ch. 18.3 - Prob. 12CYPCh. 18.L1 - Which of the following is/are a pyogenic...Ch. 18.L1 - The coagulase text is used primarily to...Ch. 18.L1 - Prob. 3MCQCh. 18.L1 - The most severe streptococcal diseases are caused...Ch. 18.L1 - 5. Rheumatic fever damages the _______, and...Ch. 18.L1 - ______ hemolysis is the partial lysis of red blood...Ch. 18.L1 - Prob. 7MCQCh. 18.L1 - Which of the following strains of pathogens has...Ch. 18.L1 - Otitis media is a/an _______ infection often...Ch. 18.L1 - Prob. 10MCQCh. 18.L1 - Prob. 11MCQCh. 18.L1 - Prob. 12MCQCh. 18.L1 - Prob. 13MCQCh. 18.L1 - Which infectious agent of those covered in the...Ch. 18.L1 - Prob. 15MCQCh. 18.L1 - Prob. 16MCQCh. 18.L1 - The first step in the clinical diagnosis of...Ch. 18.L1 - Vaccination can provide protection against N....Ch. 18.L1 - In this case, the first step taken to treat...Ch. 18.L1 - Prob. 1WCCh. 18.L1 - What conditions favor staph food poisoning?Ch. 18.L1 - Prob. 3WCCh. 18.L1 - Prob. 4WCCh. 18.L1 - Discuss the apparent pathology at work in...Ch. 18.L1 - Prob. 6WCCh. 18.L1 - a. Compare and contrast the characteristics of...Ch. 18.L2 - You have been handed the problem of diagnosing...Ch. 18.L2 - You have been called upon to prevent outbreaks of...Ch. 18.L2 - Prob. 3CTCh. 18.L2 - Prob. 4CTCh. 18.L2 - Prob. 5CTCh. 18.L2 - Prob. 6CTCh. 18.L2 - Prob. 1VCCh. 18.L2 - Prob. 2VC
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