Foundations in Microbiology
10th Edition
ISBN: 9781259705212
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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Chapter 18.1, Problem 4CYP
List the strategies commonly used to prevent and treat staphylococcal injections.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 18 Solutions
Foundations in Microbiology
Ch. 18.1 - Prob. 1ELOCh. 18.1 - Describe the ability of S. aureus to withstand...Ch. 18.1 - Prob. 3ELOCh. 18.1 - Summarize the cutaneous, systemic, and toxigenic...Ch. 18.1 - Prob. 5ELOCh. 18.1 - Explain strategies used to prevent and treat...Ch. 18.1 - Prob. 1CYPCh. 18.1 - Discuss why food intoxication in salty foods, such...Ch. 18.1 - Explain how unbroken skin, the phagocytic action...Ch. 18.1 - List the strategies commonly used to prevent and...
Ch. 18.1 - Explain the meanings of the acronyms MRSA, VRE,...Ch. 18.2 - Name the most important human pathogens in the...Ch. 18.2 - Summarize the virulence factors of S. pyogenes, as...Ch. 18.2 - Prob. 9ELOCh. 18.2 - Explain strategies used to prevent and treat...Ch. 18.2 - Relate the pathogenesis and epidemiology of S....Ch. 18.2 - List the clinically significant pathogens in the...Ch. 18.2 - Describe the immediate effects and long-term...Ch. 18.2 - Prob. 8CYPCh. 18.2 - Differentiate between pneumococcal disease...Ch. 18.3 - Name the most important human pathogens in the...Ch. 18.3 - Compare the differences in pathologies of N....Ch. 18.3 - Summarize the pathogenesis and epidemiology of N....Ch. 18.3 - Recall the medically important genera, besides...Ch. 18.3 - Describe the epidemiology and pathology of N....Ch. 18.3 - List the short-term and long-term consequences of...Ch. 18.3 - Prob. 12CYPCh. 18.L1 - Which of the following is/are a pyogenic...Ch. 18.L1 - The coagulase text is used primarily to...Ch. 18.L1 - Prob. 3MCQCh. 18.L1 - The most severe streptococcal diseases are caused...Ch. 18.L1 - 5. Rheumatic fever damages the _______, and...Ch. 18.L1 - ______ hemolysis is the partial lysis of red blood...Ch. 18.L1 - Prob. 7MCQCh. 18.L1 - Which of the following strains of pathogens has...Ch. 18.L1 - Otitis media is a/an _______ infection often...Ch. 18.L1 - Prob. 10MCQCh. 18.L1 - Prob. 11MCQCh. 18.L1 - Prob. 12MCQCh. 18.L1 - Prob. 13MCQCh. 18.L1 - Which infectious agent of those covered in the...Ch. 18.L1 - Prob. 15MCQCh. 18.L1 - Prob. 16MCQCh. 18.L1 - The first step in the clinical diagnosis of...Ch. 18.L1 - Vaccination can provide protection against N....Ch. 18.L1 - In this case, the first step taken to treat...Ch. 18.L1 - Prob. 1WCCh. 18.L1 - What conditions favor staph food poisoning?Ch. 18.L1 - Prob. 3WCCh. 18.L1 - Prob. 4WCCh. 18.L1 - Discuss the apparent pathology at work in...Ch. 18.L1 - Prob. 6WCCh. 18.L1 - a. Compare and contrast the characteristics of...Ch. 18.L2 - You have been handed the problem of diagnosing...Ch. 18.L2 - You have been called upon to prevent outbreaks of...Ch. 18.L2 - Prob. 3CTCh. 18.L2 - Prob. 4CTCh. 18.L2 - Prob. 5CTCh. 18.L2 - Prob. 6CTCh. 18.L2 - Prob. 1VCCh. 18.L2 - Prob. 2VC
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