Human Anatomy & Physiology Plus Mastering A&P with Pearson eText -- Access Card Package (2nd Edition) (What's New in Anatomy & Physiology)
2nd Edition
ISBN: 9780134702339
Author: Erin C. Amerman
Publisher: PEARSON
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Chapter 18.5, Problem 5QC
Where in the capillary does net filtration take place? Why? Where in the capillary does net absorption take place? Why?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 18 Solutions
Human Anatomy & Physiology Plus Mastering A&P with Pearson eText -- Access Card Package (2nd Edition) (What's New in Anatomy & Physiology)
Ch. 18.1 - Define the three types of blood vessels in the...Ch. 18.1 - Prob. 2QCCh. 18.1 - Prob. 3QCCh. 18.1 - Prob. 4QCCh. 18.1 - Prob. 5QCCh. 18.1 - 6. How do veins differ structurally and...Ch. 18.1 - Prob. 7QCCh. 18.1 - What are venous valves, and what are their...Ch. 18.1 - Prob. 9QCCh. 18.2 - Prob. 1QC
Ch. 18.2 - Prob. 2QCCh. 18.2 - Prob. 3QCCh. 18.2 - Prob. 4QCCh. 18.2 - Prob. 5QCCh. 18.2 - Prob. 6QCCh. 18.2 - 7. How does mean arterial pressure differ from...Ch. 18.2 - Prob. 8QCCh. 18.2 - Prob. 9QCCh. 18.3 - Prob. 1QCCh. 18.3 - Prob. 2QCCh. 18.3 - Prob. 3QCCh. 18.3 - Prob. 4QCCh. 18.3 - Prob. 5QCCh. 18.3 - Prob. 6QCCh. 18.3 - Prob. 7QCCh. 18.3 - 8. What is circulatory shock, and why is it...Ch. 18.4 - Describe the structure and size of a typical...Ch. 18.4 - 2. List three ways in which substances may cross...Ch. 18.4 - 3. Describe the properties of the three types of...Ch. 18.4 - 4. What is tissue perfusion?
Ch. 18.4 - Prob. 5QCCh. 18.4 - Prob. 6QCCh. 18.4 - Prob. 7QCCh. 18.4 - Prob. 8QCCh. 18.4 - Prob. 9QCCh. 18.5 - What is hydrostatic pressure? How does hydrostatic...Ch. 18.5 - 2. In which direction does the hydrostatic...Ch. 18.5 - 3. What is colloid osmotic pressure? In which...Ch. 18.5 - Prob. 4QCCh. 18.5 - Where in the capillary does net filtration take...Ch. 18.5 - Prob. 6QCCh. 18.6 - List the three branches of the aortic arch.Ch. 18.6 - Prob. 2QCCh. 18.6 - 3. What is the cerebral arterial circle, and what...Ch. 18.6 - Prob. 4QCCh. 18.6 - Which arteries supply the anterior and posterior...Ch. 18.6 - Prob. 6QCCh. 18.6 - Which artery supplies the upper limb?Ch. 18.6 - Trace the arterial supply of the upper limb from...Ch. 18.6 - 9. Which artery supplies the lower limb?
Ch. 18.6 - Trace the arterial supply of the lower limb from...Ch. 18.6 - Prob. 11QCCh. 18.7 - Where do most veins superior to the diaphragm...Ch. 18.7 - Prob. 2QCCh. 18.7 - Where are the dural sinuses located? What drains...Ch. 18.7 - How does drainage of the posterior body wall...Ch. 18.7 - 5. Which abdominal vessels drain straight into...Ch. 18.7 - Prob. 6QCCh. 18.7 - Prob. 7QCCh. 18.7 - Prob. 8QCCh. 18.7 - Prob. 9QCCh. 18.7 - Prob. 10QCCh. 18 - Prob. 1CYRCh. 18 - Locations where vessels connect via collateral...Ch. 18 - 3. The carotid sinus contains:
a....Ch. 18 - 4. Which of the following factors would increase...Ch. 18 - Which of the following would produce a decrease in...Ch. 18 - Fill in the blanks: The two pressures within the...Ch. 18 - The lowest pressure in the systemic circuit occurs...Ch. 18 - Explain the mechanisms that assist in the return...Ch. 18 - Mark the following statements as true or false. If...Ch. 18 - Prob. 10CYRCh. 18 - Capillaries consist of: a. three thin tunics. b....Ch. 18 - List three ways in which substances can cross the...Ch. 18 - Which of the following structures is the leakiest?...Ch. 18 - Prob. 14CYRCh. 18 - 15. The hydrostatic pressure gradient drives water...Ch. 18 - Prob. 16CYRCh. 18 - Match the following arteries with the correct...Ch. 18 - Which of the following is not a common pulse...Ch. 18 - 19. Which of the following vessels does not drain...Ch. 18 - Match the following veins with the correct...Ch. 18 - 1. Explain why a severed artery spurts blood,...Ch. 18 - 2. Explain why a person who is 7 feet tall is...Ch. 18 - Prob. 3CYUCh. 18 - Prob. 1AYKACh. 18 - 2. Mr. Gupta has been diagnosed with nephrotic...Ch. 18 - Predict the effects of each of the following on...Ch. 18 - Prob. 4AYKBCh. 18 - Ms. Rodgers has been diagnosed with secretion of...
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