Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 18, Problem 6PDQ
Explain how a tissue-specific RNA-binding protein can lead to tissue-specific alternative splicing via splicing enhancers or splicing silencers.
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Chapter 18 Solutions
Concepts of Genetics (12th Edition)
Ch. 18 - Some mutations in the tra gene of Drosophila cause...Ch. 18 - Some scientists use the analogy that the...Ch. 18 - Consider the example that actin mRNA localization...Ch. 18 - What is alternative splicing, where does it occur,...Ch. 18 - What role might the expanded tri- and...Ch. 18 - DM1 is characterized by a phenomenon known as...Ch. 18 - HOW DO WE KNOW? In this chapter, we focused on how...Ch. 18 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 18 - List three types of alternative splicing patterns...Ch. 18 - Consider the CT/CGRP example of alternative...
Ch. 18 - Explain how the use of alternative promoters and...Ch. 18 - Explain how a tissue-specific RNA-binding protein...Ch. 18 - The regulation of mRNA decay relies heavily upon...Ch. 18 - Nonsense-mediated decay is an mRNA surveillance...Ch. 18 - AU-rich elements (AREs) are cis-elements in mRNAs...Ch. 18 - What are processing bodies (P bodies), and what...Ch. 18 - In 1998, future Nobel laureates Andrew Fire and...Ch. 18 - Present an overview of RNA interference (RNAi)....Ch. 18 - RNAi may be directed by small interfering RNAs...Ch. 18 - Prob. 14PDQCh. 18 - In principle, RNAi may be used to fight viral...Ch. 18 - Prob. 16PDQCh. 18 - Prob. 17PDQCh. 18 - Prob. 18PDQCh. 18 - Prob. 19PDQCh. 18 - How is it possible that a given mRNA in a cell is...Ch. 18 - Prob. 21PDQCh. 18 - Prob. 22PDQCh. 18 - Prob. 23PDQCh. 18 - Prob. 24ESPCh. 18 - Prob. 25ESPCh. 18 - Mutations in the low-density lipoprotein receptor...Ch. 18 - RNA helicases are a class of proteins that bind...Ch. 18 - While miRNA response elements (MREs) may be...Ch. 18 - RNAi is currently being tested as a therapeutic...Ch. 18 - The localization and translational control of...Ch. 18 - Explain how the expression of a single gene can be...
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- Explain how self splicing occurs. Don't specify the base sequence of 5 prime and 3 prime splice sites. Only overall of how self splicing occurs.arrow_forwardComparison of different tissues shows that the ITY gene produces a 900 nt mature mRNA and a 190 amino acid long protein in peripheral nerves, but in another tissue, the same gene produces a 720 nt long mRNA and a larger protein, 130 amino acid long. This is a result of alternative splicing. a. For this difference to result from alternative splicing, does there need to be a difference in the DNA sequence between the ITY gene in the peripheral nerves, and the ITY gene in the other tissue? Yes Explain your reasoning: No b. If an entire exon is included in one tissue, and excluded in the other, what is the length, in nucleotides, of the alternatively-spliced exon? c. Which part(s) of the protein have difference sequences in the two types of nerves, the N- terminus, C-terminus, or middle of the protein? i. N-terminus ii. C-terminus iii. Somewhere in the middle of the proteinarrow_forwardResults of dsx splicing when tra is present?arrow_forward
- Explain how the expression of a single gene can be quickly,efficiently,and specifically shut down at the transcriptional,posttranscriptional,and posttranslational stages through thecoordinated expression of a transcriptional repressor, an miRNA,and a ubiquitin ligase.arrow_forwardDiscuss how the expression of a protein can be regulated post transcription in eukaryotic cells through, using the following key terms: Degradation of mRNA (two ways) Blocking translation Degradation of the proteinarrow_forwardSplicing machinery must recognize three portions of the precursor RNA molecule: the 5’ splice site, the 3’ splice site, and the exon junction complex (EJC). True or falsearrow_forward
- Match each of the following descriptions to the type of regulatory RNA affecting a "target" gene (aka, the gene the regulatory RNA is regulating). Use each answer once. This regulatory RNA may increase siRNA transcription of the target gene by recruiting activator proteins. secondary structures on RNA can become... IncRNA these regulatory RNAs regulate gene miRNA expression post transcriptionally generally by binding to the 3'-UTR regions of their target RNAs > >arrow_forwardDescribe how mature messenger ribonucleic acids (MRNAS) are post-transcriptionally processed in the nucleus before they are transported to the cytoplasm of a eukaryotic cell.arrow_forwardList two different ways in which trans-acting small RNAs(sRNAs) regulate the expression of target genes.arrow_forward
- Please compare the effect of an active enhancer at the level of RNA transcription with the effect of an active enhancer at the level of RNA splicingarrow_forwardWhat is the function of a splicing factor? Explain how splicing factors can regulate the cell-specific splicing of mRNAs.arrow_forwardExplain how each of the following processes complicates the concept of colinearity. Q. Trans-splicingarrow_forward
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