MOLECULAR BIOLOGY OF THE CELL
6th Edition
ISBN: 9780393870947
Author: ALBERTS
Publisher: NORTON
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Chapter 18, Problem 6P
Summary Introduction
To explain: The reason why Apaf1 and caspases 9 in the same apoptotic pathway differ in web-cell apoptosis in mice.
Concept introduction: Apoptotic protease activating factor-1 (Apaf1) is an adaptor protein to which the cytochrome c released from the mitochondria into the cytosol binds to and forms the heptamer apoptosome complex by oligomerization. The Apaf1 proteins then recruit the initiator caspase in the intrinsic pathway of apoptosis.
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