EBK ESSENTIAL ORGANIC CHEMISTRY
3rd Edition
ISBN: 9780100659469
Author: Bruice
Publisher: YUZU
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 18, Problem 40P
Trisephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehydes-3-phosphate. The enzyme’s catalytic groups are Giu 165 and His 95. In the first step of the reaction, these catalytic groups function as a base and an acid catalyst, respectively. Propose a mechanism for the reaction.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
PROBLEM 5+
What is the major product of each of the following reactions?
a. CH3CH2CHCH3 + HBr
d.
+ HBr
A
OH
OH
CH3
CH3
e.
b.
-OH + HCI
+ HCl
A,
OH
CH3
OH
CH3
c. CH3C CHCH3 + HBr
CH3 OH
f.
CHCH3 + HCl ^>
One suggestion for solving the fuel shortage due to decreasing volumes of fossil fuels
are hydrogen / oxygen fuel cells.
a. State the two half-cell reaction equations for such fuel cells. Calculate the cell
potential as well as the electrical work gained by this fuel cell at standard conditions
with E002/H20 = 1.229 V.
b. Compare the fuel cell to the Gibbs free energy of the combustion reaction of
n-octane at standard conditions. Use ASºm, n-Oct., 1 = 361.2 J/mol K.
a. Determine the electrochemical potential of the following cell using
E°Mg2+/Mg = -2.362 V.
Mg | Mg2+ (a=104) || H* (a = 4) | H2 (p
= 0.5 bar) | Pt
b. A galvanic chain consists of Co²+ / Co and Ag+ / Ag half-cells with
EºCo²+/Co = -0.282 V and Eº Ag+/Ag = 0.799 V. Determine which half-cell will be
reduced and which one will be oxidised. Furthermore, calculate the electrochemical
potential as well as the equilibrium constant of the whole cell at
i. [Co²+] = 0.1 M and [Ag+] = 0.5 M
ii. [Co²+] = 0.001 M and [Ag*] = 1.5 M
Chapter 18 Solutions
EBK ESSENTIAL ORGANIC CHEMISTRY
Ch. 18.1 - Prob. 1PCh. 18.2 - If H218O were used to hydrolyze lysozyme, which...Ch. 18.3 - Which of the following amino acid side chains can...Ch. 18.3 - Arginine and lysine side chains fit into trypsins...Ch. 18.4 - Which of the following amino acid side chains can...Ch. 18.4 - Prob. 6PCh. 18.5 - Prob. 7PCh. 18.5 - Draw the mechanism for the hydroxide-ion-catalyzed...Ch. 18.5 - What advantage does the enzyme gain by forming an...Ch. 18.7 - Prob. 10P
Ch. 18.7 - Prob. 11PCh. 18.8 - How many conjugated double bonds are there in a....Ch. 18.8 - Instead of adding to the 4a-position and...Ch. 18.8 - In succinate dehydrogenase, FAD is covalently...Ch. 18.8 - Prob. 15PCh. 18.9 - Acetolactate synthase is another TPP-requiring...Ch. 18.9 - Acetolactate synthase can also transfer the acyl...Ch. 18.9 - Prob. 18PCh. 18.9 - Prob. 19PCh. 18.10 - Prob. 21PCh. 18.11 - Prob. 23PCh. 18.11 - Which compound is more easily decarboxylated?Ch. 18.11 - Explain why the ability of PLP to catalyze an...Ch. 18.11 - Explain why the ability of PLP to catalyze an...Ch. 18.12 - What groups are interchanged in the following...Ch. 18.13 - Why is the coenzyme called tetrahydrofolate?Ch. 18.13 - What amino acid is formed by the following...Ch. 18.13 - How do the structures of tetrahydrofolate and...Ch. 18.13 - What is the source of the methyl group in...Ch. 18 - Prob. 32PCh. 18 - Prob. 33PCh. 18 - From what vitamins are the following coenzymes...Ch. 18 - Prob. 35PCh. 18 - For each of the following reaction, name both the...Ch. 18 - Explain why serine proteases do not catalyze...Ch. 18 - Prob. 38PCh. 18 - For each of the following enzyme catalyzed...Ch. 18 - Trisephosphate isomerase (TIM) catalyzes the...Ch. 18 - Prob. 41PCh. 18 - What acyl groups have we seen transferred by...Ch. 18 - When UMP is dissolved in T2O, exchange of T for H...Ch. 18 - Prob. 44PCh. 18 - When transaminated, the three branched-chain amino...Ch. 18 - Aldolase shows no activity if it is incubated with...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Similar questions
- The equilibrium voltage of the following cell has been measured at 0.522 V at 25 °C. Pt | H2, g❘ HClaq || AgClaq | Ags State the redox reactions present in this cell. Calculate the pH value of the electrolyte solution with KL, AgCl = 1.96 · 10-10 mol² / L². Assume that the concentrations of H+ and Clare equal.arrow_forwardHere are the energies (in kcal/mol) for staggered and eclipsed interactions for CH, CC, and CBr bonds eclipsed (0°) staggered (60°) bonds CH/CH 1.0 0.0 CH/CC 1.3 0.0 Br: CC/CC 3.0 0.9 Br CH/CBr 1.8 0.0 CC / CBr 3.3 1.0 CBr / CBr 3.7 1.2 a) I've drawn the Newman projection for one of the staggered conformations of the molecule above, looking down the C2-C3 bond. Draw Newman projections for the other two staggered and the three eclipsed conformations (in order). CH₂ H3C. H' H Br b) Calculate the relative energies for each of the conformations and write them below each conformation.arrow_forward90. Draw the stereoisomers obtained from each of the following reactions: a. H₂ b. H₂ C. H₂ Pd/C Pd/C Pd/Carrow_forward
- 36. The emission spectrum below for a one-electron (hydrogen-like) species in the gas phase shows all the lines, before they merge together, resulting from transitions to the first excited state from higher energy states. Line A has a wavelength of 434 nm. BA Increasing wavelength, λ (a) What are the upper and lower principal quantum numbers corresponding to the lines labeled A and B? (b) Identify the one-electron species that exhibits the spectrum.arrow_forwardf) The unusual molecule [2.2.2] propellane is pictured. 1) Given the bond length and bond angles in the image, what hybridization scheme best describes the carbons marked by the askerisks? 2) What types of orbitals are used in the bond between the two carbons marked by the askerisks? 3) How does this bond compare to an ordinary carbon-carbon bond (which is usually 1.54 Å long)? H₂C H₂C CH2 1.60Å ハ C. * CH₂ H₂C * C H₂ 120°arrow_forwardQuestion Resonance Forms a) Draw all resonance forms of the molecules. Include curved arrow notation. Label major resonance contributor Resonance Forms a) Draw all resonance forms of the molecules. Include curved arrow notation. Label major resonance contributorarrow_forward
- Can you show me or determine the longest carbon chain, which is octane? Potentially highlight it in different sections to show me, plz, or individually?arrow_forwardPLEASE ANSWER ALL PARTS!!arrow_forwardd) Determine the formal charge on the nitrogen atom in each of the structures. NH3 NH2 N C бобкат : N N H H Н H2N-OH A B C D E F Garrow_forward
- Lewis Structure, Hybridization & Molecular Geometry a) Draw the Lewis Structure of the molecules; Label the hybridization of each carbon atom; Predict the approximate molecular geometry around each carbon atom. CH3CHO CH3CN b) Draw the Lewis Structure of Nitromethane; Predict the approximate molecular geometry around the nitrogen atom. CH3NO2 c) Draw the Lewis Structure; Label the hybridization of the boron atom; Predict the approximate molecular geometry. BF3 BF4arrow_forwarda. The structure of the bicarbonate (hydrogen carbonate) ion, HCO3-, HCO3 " is best described as a hybrid of several contributing resonance forms, two of which are shown here. HO :0: HO + :Ö: Bicarbonate is crucial for the control of body pH (for example, blood pH 7.4). A more self-indulgent use is in baking soda, where it serves as a source of CO2 CO2 gas, which gives bread and pastry their fluffy constituency. (i) Draw at least one additional resonance form. = (ii) Using curved "electron-pushing" arrows, show how these Lewis structures may be interconverted by movement of electron pairs. (iii) Determine which form or forms will be the major contributor(s) to the real structure of bicarbonate, explaining your answer on the basis of the criteria in Section 1-5.arrow_forwardCalibri 11 + BIL NAME: Jaylena M A student is investigating the ctect of volume on pressure during a lab activity. The student uses the following volumes (mL). 12, 13, 14, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28, 30, 33, 34, 35, 38, 40, 42, 44. 46, and 50. As the volume changed they measured the following pressures (atm) 11.0, 10.5, 10.0, 9.2. 8.5, 78, 75, 7.0, 6.8, 6.5, 6.0, 5.9, 5.5, 5.0, 4.8, 4.5, 4.2, 3.9, 3.8, 3.5, 3.3, 3.2, 3.0, 2.9. What is the independent variable? Volume Imla What is the dependent variable? Pressure Jatm Use the data and make a PROPER data table. Volume 1mL) Pressure latm 110arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Chemistry for Today: General, Organic, and Bioche...ChemistryISBN:9781305960060Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. HansenPublisher:Cengage Learning
Introductory Chemistry: A FoundationChemistryISBN:9781337399425Author:Steven S. Zumdahl, Donald J. DeCostePublisher:Cengage Learning
World of Chemistry, 3rd editionChemistryISBN:9781133109655Author:Steven S. Zumdahl, Susan L. Zumdahl, Donald J. DeCostePublisher:Brooks / Cole / Cengage Learning
World of ChemistryChemistryISBN:9780618562763Author:Steven S. ZumdahlPublisher:Houghton Mifflin College Div
General, Organic, and Biological ChemistryChemistryISBN:9781285853918Author:H. Stephen StokerPublisher:Cengage Learning
Chemistry for Today: General, Organic, and Bioche...
Chemistry
ISBN:9781305960060
Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Publisher:Cengage Learning
Introductory Chemistry: A Foundation
Chemistry
ISBN:9781337399425
Author:Steven S. Zumdahl, Donald J. DeCoste
Publisher:Cengage Learning
World of Chemistry, 3rd edition
Chemistry
ISBN:9781133109655
Author:Steven S. Zumdahl, Susan L. Zumdahl, Donald J. DeCoste
Publisher:Brooks / Cole / Cengage Learning
World of Chemistry
Chemistry
ISBN:9780618562763
Author:Steven S. Zumdahl
Publisher:Houghton Mifflin College Div
General, Organic, and Biological Chemistry
Chemistry
ISBN:9781285853918
Author:H. Stephen Stoker
Publisher:Cengage Learning
DIGESTER-35 | VITAMINS AND THEIR RELATED COENZYMES| GPAT | NIPER | PHARMACIST| DI; Author: GPAT DISCUSSION CENTER;https://www.youtube.com/watch?v=CGrdNYmho0s;License: Standard YouTube License, CC-BY