The type of reaction in which leucine is converted to α-ketoisocaproate. Introduction : The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

Question

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Answer 1

Question

Chapter 18, Problem 19P

(a)

Summary Introduction

To determine: The type of reaction in which leucine is converted to α-ketoisocaproate.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(a)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 1 represents the transamination reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 1

Fig. 1: Transamination reaction.

Explanation:

The transamination reaction is involved in the conversion of leucine into alpha ketoisocaproate. The co-factor involved in this reaction is PLP (pyridoxal phosphate). There is no analogous reaction to this reaction from citric acid cycle and β-oxidation.

(b)

Summary Introduction

To determine: The type of reaction in which Ketoisocaproate is converted to Isovaleryl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(b)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 2 represents the oxidative decarboxylation.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 2

Fig. 2: Oxidative decarboxylation.

Explanation:

The oxidative decarboxylation is occurring that converts Ketoisocaproate to Isovaleryl-CoA. The cofactors involved are “NAD⁺ (Nicotinamide adenine dinucleotide)”, “TPP (Triphenyl phosphate)” and “FAD (Flavin adenine dinucleotide)”, and “lipoate”. The formation of acetyl CoA by oxidative decarboxylation of pyruvate is similar to this given reaction.

(c)

Summary Introduction

To determine: The type of reaction in which Isovaleryl-CoA is converted to β-methylcrotonyl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(c)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 3 represents the dehydrogenation reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 3

Fig. 3: Dehydrogenation reaction.

Explanation:

The type of reaction in which Isovaleryl-CoA is converted to β-methylcrotonyl-CoA is dehydrogenation. The cofactor is (FAD) Flavin adenine nucleotide. The analogous reaction is formation of fumarate by succinate dehydrogenation in citric acid cycle. Another analogous reaction is formation of enoyl CoA by fatty acyl CoA in β-oxidation.

(d)

Summary Introduction

To determine: The type of reaction in which beta methylcrotonyl-CoA is converted to beta-methylglutaconyl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(d)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 4 represents the carboxylation reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 4

Fig. 4: Carboxylation reaction.

Explanation:

The formation of β-methylglutaconyl-CoA by β-methylcrotonyl-CoA is a type of carboxylation reaction. The cofactors are biotin and ATP. This step is not analogous to any step in β-oxidation and citric acid cycle.

(e)

Summary Introduction

To determine: The type of reaction in which beta-methylglutaconyl-CoA is converted to β-hydroxy β-methylglutaryl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(e)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 5 represents the hydration reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 5

Fig. 5: Hydration reaction.

Explanation:

The conversion of beta-methylglutaconyl-CoA into β-hydroxy β-methylglutaryl-CoA is a type of hydration reaction. This reaction does not require the cofactors. The formation of malate by fumarate and formation of 3-hydroxyacyl-CoA by enoyl-CoA are analogous to this given reaction.

(f)

Summary Introduction

To determine: The type of reaction in which β-hydroxy β-methylglutaryl-CoA is converted to acetyl-CoA and acetoacetate.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(f)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 6 represents the reverse aldol reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 6

Fig. 6: Reverse aldol reaction.

Explanation:

The formation of acetate-CoA and acetoacetate by β-hydroxy β-methylglutaryl-CoA is a type of reverse aldol reaction. There are no cofactors involved in this reaction. The analogous reaction is the opposite reaction involving citrate synthase. This reaction is analogous to citrate synthase reaction in the citric acid cycle. It is identical to the cleavage of β-hydroxy-β-methylglutaryl-CoA in the formation of ketone bodies.

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Answer 2

Question

Chapter 18, Problem 19P

(a)

Summary Introduction

To determine: The type of reaction in which leucine is converted to α-ketoisocaproate.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(a)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 1 represents the transamination reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 1

Fig. 1: Transamination reaction.

Explanation:

The transamination reaction is involved in the conversion of leucine into alpha ketoisocaproate. The co-factor involved in this reaction is PLP (pyridoxal phosphate). There is no analogous reaction to this reaction from citric acid cycle and β-oxidation.

(b)

Summary Introduction

To determine: The type of reaction in which Ketoisocaproate is converted to Isovaleryl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(b)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 2 represents the oxidative decarboxylation.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 2

Fig. 2: Oxidative decarboxylation.

Explanation:

The oxidative decarboxylation is occurring that converts Ketoisocaproate to Isovaleryl-CoA. The cofactors involved are “NAD⁺ (Nicotinamide adenine dinucleotide)”, “TPP (Triphenyl phosphate)” and “FAD (Flavin adenine dinucleotide)”, and “lipoate”. The formation of acetyl CoA by oxidative decarboxylation of pyruvate is similar to this given reaction.

(c)

Summary Introduction

To determine: The type of reaction in which Isovaleryl-CoA is converted to β-methylcrotonyl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(c)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 3 represents the dehydrogenation reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 3

Fig. 3: Dehydrogenation reaction.

Explanation:

The type of reaction in which Isovaleryl-CoA is converted to β-methylcrotonyl-CoA is dehydrogenation. The cofactor is (FAD) Flavin adenine nucleotide. The analogous reaction is formation of fumarate by succinate dehydrogenation in citric acid cycle. Another analogous reaction is formation of enoyl CoA by fatty acyl CoA in β-oxidation.

(d)

Summary Introduction

To determine: The type of reaction in which beta methylcrotonyl-CoA is converted to beta-methylglutaconyl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(d)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 4 represents the carboxylation reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 4

Fig. 4: Carboxylation reaction.

Explanation:

The formation of β-methylglutaconyl-CoA by β-methylcrotonyl-CoA is a type of carboxylation reaction. The cofactors are biotin and ATP. This step is not analogous to any step in β-oxidation and citric acid cycle.

(e)

Summary Introduction

To determine: The type of reaction in which beta-methylglutaconyl-CoA is converted to β-hydroxy β-methylglutaryl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(e)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 5 represents the hydration reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 5

Fig. 5: Hydration reaction.

Explanation:

The conversion of beta-methylglutaconyl-CoA into β-hydroxy β-methylglutaryl-CoA is a type of hydration reaction. This reaction does not require the cofactors. The formation of malate by fumarate and formation of 3-hydroxyacyl-CoA by enoyl-CoA are analogous to this given reaction.

(f)

Summary Introduction

To determine: The type of reaction in which β-hydroxy β-methylglutaryl-CoA is converted to acetyl-CoA and acetoacetate.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(f)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 6 represents the reverse aldol reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 6

Fig. 6: Reverse aldol reaction.

Explanation:

The formation of acetate-CoA and acetoacetate by β-hydroxy β-methylglutaryl-CoA is a type of reverse aldol reaction. There are no cofactors involved in this reaction. The analogous reaction is the opposite reaction involving citrate synthase. This reaction is analogous to citrate synthase reaction in the citric acid cycle. It is identical to the cleavage of β-hydroxy-β-methylglutaryl-CoA in the formation of ketone bodies.

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Answer 3

Question

Chapter 18, Problem 19P

(a)

Summary Introduction

To determine: The type of reaction in which leucine is converted to α-ketoisocaproate.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(a)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 1 represents the transamination reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 1

Fig. 1: Transamination reaction.

Explanation:

The transamination reaction is involved in the conversion of leucine into alpha ketoisocaproate. The co-factor involved in this reaction is PLP (pyridoxal phosphate). There is no analogous reaction to this reaction from citric acid cycle and β-oxidation.

(b)

Summary Introduction

To determine: The type of reaction in which Ketoisocaproate is converted to Isovaleryl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(b)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 2 represents the oxidative decarboxylation.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 2

Fig. 2: Oxidative decarboxylation.

Explanation:

The oxidative decarboxylation is occurring that converts Ketoisocaproate to Isovaleryl-CoA. The cofactors involved are “NAD⁺ (Nicotinamide adenine dinucleotide)”, “TPP (Triphenyl phosphate)” and “FAD (Flavin adenine dinucleotide)”, and “lipoate”. The formation of acetyl CoA by oxidative decarboxylation of pyruvate is similar to this given reaction.

(c)

Summary Introduction

To determine: The type of reaction in which Isovaleryl-CoA is converted to β-methylcrotonyl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(c)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 3 represents the dehydrogenation reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 3

Fig. 3: Dehydrogenation reaction.

Explanation:

The type of reaction in which Isovaleryl-CoA is converted to β-methylcrotonyl-CoA is dehydrogenation. The cofactor is (FAD) Flavin adenine nucleotide. The analogous reaction is formation of fumarate by succinate dehydrogenation in citric acid cycle. Another analogous reaction is formation of enoyl CoA by fatty acyl CoA in β-oxidation.

(d)

Summary Introduction

To determine: The type of reaction in which beta methylcrotonyl-CoA is converted to beta-methylglutaconyl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(d)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 4 represents the carboxylation reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 4

Fig. 4: Carboxylation reaction.

Explanation:

The formation of β-methylglutaconyl-CoA by β-methylcrotonyl-CoA is a type of carboxylation reaction. The cofactors are biotin and ATP. This step is not analogous to any step in β-oxidation and citric acid cycle.

(e)

Summary Introduction

To determine: The type of reaction in which beta-methylglutaconyl-CoA is converted to β-hydroxy β-methylglutaryl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(e)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 5 represents the hydration reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 5

Fig. 5: Hydration reaction.

Explanation:

The conversion of beta-methylglutaconyl-CoA into β-hydroxy β-methylglutaryl-CoA is a type of hydration reaction. This reaction does not require the cofactors. The formation of malate by fumarate and formation of 3-hydroxyacyl-CoA by enoyl-CoA are analogous to this given reaction.

(f)

Summary Introduction

To determine: The type of reaction in which β-hydroxy β-methylglutaryl-CoA is converted to acetyl-CoA and acetoacetate.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(f)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 6 represents the reverse aldol reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 6

Fig. 6: Reverse aldol reaction.

Explanation:

The formation of acetate-CoA and acetoacetate by β-hydroxy β-methylglutaryl-CoA is a type of reverse aldol reaction. There are no cofactors involved in this reaction. The analogous reaction is the opposite reaction involving citrate synthase. This reaction is analogous to citrate synthase reaction in the citric acid cycle. It is identical to the cleavage of β-hydroxy-β-methylglutaryl-CoA in the formation of ketone bodies.

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Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 4

Question

Chapter 18, Problem 19P

(a)

Summary Introduction

To determine: The type of reaction in which leucine is converted to α-ketoisocaproate.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(a)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 1 represents the transamination reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 1

Fig. 1: Transamination reaction.

Explanation:

The transamination reaction is involved in the conversion of leucine into alpha ketoisocaproate. The co-factor involved in this reaction is PLP (pyridoxal phosphate). There is no analogous reaction to this reaction from citric acid cycle and β-oxidation.

(b)

Summary Introduction

To determine: The type of reaction in which Ketoisocaproate is converted to Isovaleryl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(b)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 2 represents the oxidative decarboxylation.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 2

Fig. 2: Oxidative decarboxylation.

Explanation:

The oxidative decarboxylation is occurring that converts Ketoisocaproate to Isovaleryl-CoA. The cofactors involved are “NAD⁺ (Nicotinamide adenine dinucleotide)”, “TPP (Triphenyl phosphate)” and “FAD (Flavin adenine dinucleotide)”, and “lipoate”. The formation of acetyl CoA by oxidative decarboxylation of pyruvate is similar to this given reaction.

(c)

Summary Introduction

To determine: The type of reaction in which Isovaleryl-CoA is converted to β-methylcrotonyl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(c)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 3 represents the dehydrogenation reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 3

Fig. 3: Dehydrogenation reaction.

Explanation:

The type of reaction in which Isovaleryl-CoA is converted to β-methylcrotonyl-CoA is dehydrogenation. The cofactor is (FAD) Flavin adenine nucleotide. The analogous reaction is formation of fumarate by succinate dehydrogenation in citric acid cycle. Another analogous reaction is formation of enoyl CoA by fatty acyl CoA in β-oxidation.

(d)

Summary Introduction

To determine: The type of reaction in which beta methylcrotonyl-CoA is converted to beta-methylglutaconyl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(d)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 4 represents the carboxylation reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 4

Fig. 4: Carboxylation reaction.

Explanation:

The formation of β-methylglutaconyl-CoA by β-methylcrotonyl-CoA is a type of carboxylation reaction. The cofactors are biotin and ATP. This step is not analogous to any step in β-oxidation and citric acid cycle.

(e)

Summary Introduction

To determine: The type of reaction in which beta-methylglutaconyl-CoA is converted to β-hydroxy β-methylglutaryl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(e)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 5 represents the hydration reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 5

Fig. 5: Hydration reaction.

Explanation:

The conversion of beta-methylglutaconyl-CoA into β-hydroxy β-methylglutaryl-CoA is a type of hydration reaction. This reaction does not require the cofactors. The formation of malate by fumarate and formation of 3-hydroxyacyl-CoA by enoyl-CoA are analogous to this given reaction.

(f)

Summary Introduction

To determine: The type of reaction in which β-hydroxy β-methylglutaryl-CoA is converted to acetyl-CoA and acetoacetate.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(f)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 6 represents the reverse aldol reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 6

Fig. 6: Reverse aldol reaction.

Explanation:

The formation of acetate-CoA and acetoacetate by β-hydroxy β-methylglutaryl-CoA is a type of reverse aldol reaction. There are no cofactors involved in this reaction. The analogous reaction is the opposite reaction involving citrate synthase. This reaction is analogous to citrate synthase reaction in the citric acid cycle. It is identical to the cleavage of β-hydroxy-β-methylglutaryl-CoA in the formation of ketone bodies.

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Answer 5

Chapter 18, Problem 19P

(a)

Summary Introduction

To determine: The type of reaction in which leucine is converted to α-ketoisocaproate.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(a)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 1 represents the transamination reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 1

Fig. 1: Transamination reaction.

Explanation:

The transamination reaction is involved in the conversion of leucine into alpha ketoisocaproate. The co-factor involved in this reaction is PLP (pyridoxal phosphate). There is no analogous reaction to this reaction from citric acid cycle and β-oxidation.

(b)

Summary Introduction

To determine: The type of reaction in which Ketoisocaproate is converted to Isovaleryl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(b)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 2 represents the oxidative decarboxylation.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 2

Fig. 2: Oxidative decarboxylation.

Explanation:

The oxidative decarboxylation is occurring that converts Ketoisocaproate to Isovaleryl-CoA. The cofactors involved are “NAD⁺ (Nicotinamide adenine dinucleotide)”, “TPP (Triphenyl phosphate)” and “FAD (Flavin adenine dinucleotide)”, and “lipoate”. The formation of acetyl CoA by oxidative decarboxylation of pyruvate is similar to this given reaction.

(c)

Summary Introduction

To determine: The type of reaction in which Isovaleryl-CoA is converted to β-methylcrotonyl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(c)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 3 represents the dehydrogenation reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 3

Fig. 3: Dehydrogenation reaction.

Explanation:

The type of reaction in which Isovaleryl-CoA is converted to β-methylcrotonyl-CoA is dehydrogenation. The cofactor is (FAD) Flavin adenine nucleotide. The analogous reaction is formation of fumarate by succinate dehydrogenation in citric acid cycle. Another analogous reaction is formation of enoyl CoA by fatty acyl CoA in β-oxidation.

(d)

Summary Introduction

To determine: The type of reaction in which beta methylcrotonyl-CoA is converted to beta-methylglutaconyl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(d)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 4 represents the carboxylation reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 4

Fig. 4: Carboxylation reaction.

Explanation:

The formation of β-methylglutaconyl-CoA by β-methylcrotonyl-CoA is a type of carboxylation reaction. The cofactors are biotin and ATP. This step is not analogous to any step in β-oxidation and citric acid cycle.

(e)

Summary Introduction

To determine: The type of reaction in which beta-methylglutaconyl-CoA is converted to β-hydroxy β-methylglutaryl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(e)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 5 represents the hydration reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 5

Fig. 5: Hydration reaction.

Explanation:

The conversion of beta-methylglutaconyl-CoA into β-hydroxy β-methylglutaryl-CoA is a type of hydration reaction. This reaction does not require the cofactors. The formation of malate by fumarate and formation of 3-hydroxyacyl-CoA by enoyl-CoA are analogous to this given reaction.

(f)

Summary Introduction

To determine: The type of reaction in which β-hydroxy β-methylglutaryl-CoA is converted to acetyl-CoA and acetoacetate.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(f)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 6 represents the reverse aldol reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 6

Fig. 6: Reverse aldol reaction.

Explanation:

The formation of acetate-CoA and acetoacetate by β-hydroxy β-methylglutaryl-CoA is a type of reverse aldol reaction. There are no cofactors involved in this reaction. The analogous reaction is the opposite reaction involving citrate synthase. This reaction is analogous to citrate synthase reaction in the citric acid cycle. It is identical to the cleavage of β-hydroxy-β-methylglutaryl-CoA in the formation of ketone bodies.

Answer 6

Chapter 18, Problem 19P

(a)

Summary Introduction

To determine: The type of reaction in which leucine is converted to α-ketoisocaproate.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(a)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 1 represents the transamination reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 1

Fig. 1: Transamination reaction.

Explanation:

The transamination reaction is involved in the conversion of leucine into alpha ketoisocaproate. The co-factor involved in this reaction is PLP (pyridoxal phosphate). There is no analogous reaction to this reaction from citric acid cycle and β-oxidation.

Answer 7

Chapter 18, Problem 19P

(a)

Summary Introduction

To determine: The type of reaction in which leucine is converted to α-ketoisocaproate.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

Answer 8

(a)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 1 represents the transamination reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 1

Fig. 1: Transamination reaction.

Explanation:

The transamination reaction is involved in the conversion of leucine into alpha ketoisocaproate. The co-factor involved in this reaction is PLP (pyridoxal phosphate). There is no analogous reaction to this reaction from citric acid cycle and β-oxidation.

Answer 9

(a)

Expert Solution

Answer 10

(a)

Expert Solution

Answer 11

Expert Solution

Answer 12

(b)

Summary Introduction

To determine: The type of reaction in which Ketoisocaproate is converted to Isovaleryl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(b)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 2 represents the oxidative decarboxylation.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 2

Fig. 2: Oxidative decarboxylation.

Explanation:

The oxidative decarboxylation is occurring that converts Ketoisocaproate to Isovaleryl-CoA. The cofactors involved are “NAD⁺ (Nicotinamide adenine dinucleotide)”, “TPP (Triphenyl phosphate)” and “FAD (Flavin adenine dinucleotide)”, and “lipoate”. The formation of acetyl CoA by oxidative decarboxylation of pyruvate is similar to this given reaction.

Answer 13

(b)

Summary Introduction

To determine: The type of reaction in which Ketoisocaproate is converted to Isovaleryl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

Answer 14

(b)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 2 represents the oxidative decarboxylation.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 2

Fig. 2: Oxidative decarboxylation.

Explanation:

The oxidative decarboxylation is occurring that converts Ketoisocaproate to Isovaleryl-CoA. The cofactors involved are “NAD⁺ (Nicotinamide adenine dinucleotide)”, “TPP (Triphenyl phosphate)” and “FAD (Flavin adenine dinucleotide)”, and “lipoate”. The formation of acetyl CoA by oxidative decarboxylation of pyruvate is similar to this given reaction.

Answer 15

(b)

Expert Solution

Answer 16

(b)

Expert Solution

Answer 17

Expert Solution

Answer 18

(c)

Summary Introduction

To determine: The type of reaction in which Isovaleryl-CoA is converted to β-methylcrotonyl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(c)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 3 represents the dehydrogenation reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 3

Fig. 3: Dehydrogenation reaction.

Explanation:

The type of reaction in which Isovaleryl-CoA is converted to β-methylcrotonyl-CoA is dehydrogenation. The cofactor is (FAD) Flavin adenine nucleotide. The analogous reaction is formation of fumarate by succinate dehydrogenation in citric acid cycle. Another analogous reaction is formation of enoyl CoA by fatty acyl CoA in β-oxidation.

Answer 19

(c)

Summary Introduction

To determine: The type of reaction in which Isovaleryl-CoA is converted to β-methylcrotonyl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

Answer 20

(c)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 3 represents the dehydrogenation reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 3

Fig. 3: Dehydrogenation reaction.

Explanation:

The type of reaction in which Isovaleryl-CoA is converted to β-methylcrotonyl-CoA is dehydrogenation. The cofactor is (FAD) Flavin adenine nucleotide. The analogous reaction is formation of fumarate by succinate dehydrogenation in citric acid cycle. Another analogous reaction is formation of enoyl CoA by fatty acyl CoA in β-oxidation.

Answer 21

(c)

Expert Solution

Answer 22

(c)

Expert Solution

Answer 23

Expert Solution

Answer 24

(d)

Summary Introduction

To determine: The type of reaction in which beta methylcrotonyl-CoA is converted to beta-methylglutaconyl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(d)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 4 represents the carboxylation reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 4

Fig. 4: Carboxylation reaction.

Explanation:

The formation of β-methylglutaconyl-CoA by β-methylcrotonyl-CoA is a type of carboxylation reaction. The cofactors are biotin and ATP. This step is not analogous to any step in β-oxidation and citric acid cycle.

Answer 25

(d)

Summary Introduction

To determine: The type of reaction in which beta methylcrotonyl-CoA is converted to beta-methylglutaconyl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

Answer 26

(d)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 4 represents the carboxylation reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 4

Fig. 4: Carboxylation reaction.

Explanation:

The formation of β-methylglutaconyl-CoA by β-methylcrotonyl-CoA is a type of carboxylation reaction. The cofactors are biotin and ATP. This step is not analogous to any step in β-oxidation and citric acid cycle.

Answer 27

(d)

Expert Solution

Answer 28

(d)

Expert Solution

Answer 29

Expert Solution

Answer 30

(e)

Summary Introduction

To determine: The type of reaction in which beta-methylglutaconyl-CoA is converted to β-hydroxy β-methylglutaryl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(e)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 5 represents the hydration reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 5

Fig. 5: Hydration reaction.

Explanation:

The conversion of beta-methylglutaconyl-CoA into β-hydroxy β-methylglutaryl-CoA is a type of hydration reaction. This reaction does not require the cofactors. The formation of malate by fumarate and formation of 3-hydroxyacyl-CoA by enoyl-CoA are analogous to this given reaction.

Answer 31

(e)

Summary Introduction

To determine: The type of reaction in which beta-methylglutaconyl-CoA is converted to β-hydroxy β-methylglutaryl-CoA.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen. β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

Answer 32

(e)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 5 represents the hydration reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 5

Fig. 5: Hydration reaction.

Explanation:

The conversion of beta-methylglutaconyl-CoA into β-hydroxy β-methylglutaryl-CoA is a type of hydration reaction. This reaction does not require the cofactors. The formation of malate by fumarate and formation of 3-hydroxyacyl-CoA by enoyl-CoA are analogous to this given reaction.

Answer 33

(e)

Expert Solution

Answer 34

(e)

Expert Solution

Answer 35

Expert Solution

Answer 36

(f)

Summary Introduction

To determine: The type of reaction in which β-hydroxy β-methylglutaryl-CoA is converted to acetyl-CoA and acetoacetate.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

(f)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 6 represents the reverse aldol reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 6

Fig. 6: Reverse aldol reaction.

Explanation:

The formation of acetate-CoA and acetoacetate by β-hydroxy β-methylglutaryl-CoA is a type of reverse aldol reaction. There are no cofactors involved in this reaction. The analogous reaction is the opposite reaction involving citrate synthase. This reaction is analogous to citrate synthase reaction in the citric acid cycle. It is identical to the cleavage of β-hydroxy-β-methylglutaryl-CoA in the formation of ketone bodies.

Answer 37

(f)

Summary Introduction

To determine: The type of reaction in which β-hydroxy β-methylglutaryl-CoA is converted to acetyl-CoA and acetoacetate.

Introduction:

The series of metabolic reactions, in which the energy stored in the compounds is released for the production of ATP (adenosine triphosphate), is called “Krebs’s cycle”. The pyruvate undergoes series of reactions in the citric acid cycle and converts into Acetyl CoA (acetyl coenzyme A) in the presence of oxygen.

β-oxidation is the oxidation of fatty acids in cells in absence of glucose and glycogen, to produce ATP. Oxidation takes place at the β carbon, thus, this reaction is termed as β-oxidation.

Answer 38

(f)

Expert Solution

Explanation of Solution

Pictorial representation: Fig. 6 represents the reverse aldol reaction.

Lehninger Principles of Biochemistry, Chapter 18, Problem 19P , additional homework tip 6

Fig. 6: Reverse aldol reaction.

Explanation:

The formation of acetate-CoA and acetoacetate by β-hydroxy β-methylglutaryl-CoA is a type of reverse aldol reaction. There are no cofactors involved in this reaction. The analogous reaction is the opposite reaction involving citrate synthase. This reaction is analogous to citrate synthase reaction in the citric acid cycle. It is identical to the cleavage of β-hydroxy-β-methylglutaryl-CoA in the formation of ketone bodies.