Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
7th Edition
ISBN: 9781464126116
Author: David L. Nelson, Michael M. Cox
Publisher: W. H. Freeman
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Chapter 18, Problem 15P
Summary Introduction

To suggest: A mechanism for the reaction which is based on the mechanism in Figure 18-6. The reaction involves threonine elimination at β-carbon.

Introduction:

Threonine dehydrogenase is the enzyme which is responsible for the breakdown of threonine. This enzyme also catalyzes the conversion of threonine to α-ketobutyrate and ammonia. The PLP or pyridoxal phosphate acts as the cofactor in the conversion of threonine to α-ketobutyrate and ammonia.

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