GENERAL,ORGANIC, & BIOLOGICAL CHEM-ACCES
4th Edition
ISBN: 9781265982959
Author: SMITH
Publisher: MCG
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Textbook Question
Chapter 1.8, Problem 1.12PP
A patient is prescribed 0.100 mg of a drug that is available in
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need help please and thanks dont understand only need help with C-F
Learning Goal:
As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT.
The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7).
Part A - Difference in binding free eenergies
Compute the difference in binding free energy (at a physiological temperature T=310 K) for the complexes. Provide the difference as a positive numerical expression with three significant figures in kJ/mol.
The margin of error is 2%.
Part B - Compare difference in free energy to the thermal…
Please correct answer and don't used hand raiting
need help please and thanks dont understand a-b
Learning Goal:
As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT.
The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7).
Part A - Difference in binding free eenergies
Compute the difference in binding free energy (at a physiological temperature T=310 K) for the complexes. Provide the difference as a positive numerical expression with three significant figures in kJ/mol.
The margin of error is 2%.
Part B - Compare difference in free energy to the thermal energy
Divide the…
Chapter 1 Solutions
GENERAL,ORGANIC, & BIOLOGICAL CHEM-ACCES
Ch. 1.1 - Prob. 1.1PCh. 1.2 - Characterize each process as a physical change or...Ch. 1.2 - Does the molecular art represent a chemical change...Ch. 1.3 - Classify each example of molecular art as a pure...Ch. 1.3 - (a) Which representation(s) of molecular art...Ch. 1.3 - Classify each item as a pure substance or a...Ch. 1.3 - Classify each item as an element or a compound:...Ch. 1.4 - What term is used for each of the following units:...Ch. 1.4 - If a nanometer is one-billionth of a meter...Ch. 1.4 - Prob. 1.8P
Ch. 1.4 - Using the prefixes in Table 1.2, determine which...Ch. 1.5 - How many significant figures does each number...Ch. 1.5 - Indicate whether each zero in the following...Ch. 1.5 - Round off each number in Sample Problem 1.4 to two...Ch. 1.5 - Carry out each caluction and give the answer using...Ch. 1.5 - Carry out each calculation and give the answer...Ch. 1.6 - Write each number in scientific notation. 93,200...Ch. 1.6 - Lab results for a routine check-up showed an...Ch. 1.6 - Convert each number to its standard form. 6.5103...Ch. 1.7 - Write two conversion factors for each pair of...Ch. 1.7 - Carry out each of the following conversions. 25 L...Ch. 1.7 - On a flight from Bangkok, Thailand, to Taipei,...Ch. 1.7 - What is the volume of liquid contained in the...Ch. 1.7 - Carry out each of the following conversions. 6,250...Ch. 1.8 - A patient is prescribed 0.100 mg of a drug that is...Ch. 1.8 - Prob. 1.13PPCh. 1.8 - Prob. 1.14PCh. 1.9 - Prob. 1.14PPCh. 1.9 - Prob. 1.15PCh. 1.10 - How does the mass of liquid A in cylinder [1]...Ch. 1.10 - Calculate the mass in grams of 10.0 mL of diethyl...Ch. 1.10 - If a 120-lb woman uses five 2.0lb lead weights in...Ch. 1.10 - If a household recycles 10.5 kg of plastic bottles...Ch. 1.10 - If the density of a liquid is 0.80 g/mL, what is...Ch. 1 - Classify each example of molecular art as a pure...Ch. 1 - (a) Which representation(s) in Problem 1.19...Ch. 1 - Label each component in the molecular art as an...Ch. 1 - Label each component in the molecular art as an...Ch. 1 - (a) Which representation(s) illustrate a mixture...Ch. 1 - Label each of the following conversions as a...Ch. 1 - Classify each process as a chemical or physical...Ch. 1 - Classify each process as a chemical or physical...Ch. 1 - When a chunk of dry ice (solid carbon dioxide) is...Ch. 1 - The inexpensive preparation of nitrogen-containing...Ch. 1 - What is the temperature on the given Fahrenheit...Ch. 1 - a. What is the length of the given crayon in...Ch. 1 - Label each quantity as an exact or inexact number....Ch. 1 - Label each quantity as an exact or inexact number....Ch. 1 - Which quantity in each pair is larger? 5 mL or 5...Ch. 1 - Which quantity in each pair is larger? 10 km or 10...Ch. 1 - How many significant figures does each number...Ch. 1 - Prob. 36PCh. 1 - Prob. 37PCh. 1 - Prob. 38PCh. 1 - Prob. 39PCh. 1 - Prob. 40PCh. 1 - Prob. 41PCh. 1 - Prob. 42PCh. 1 - Prob. 43PCh. 1 - Prob. 44PCh. 1 - Prob. 45PCh. 1 - Rank the numbers in each group from smallest to...Ch. 1 - Prob. 47PCh. 1 - Prob. 48PCh. 1 - Prob. 49PCh. 1 - What is the volume of liquid contained in the...Ch. 1 - Prob. 51PCh. 1 - (a) If there are 15 mL in one tablespoon, how many...Ch. 1 - The concentration of mercury, a toxi pollutant, in...Ch. 1 - Prob. 54PCh. 1 - Prob. 55PCh. 1 - Prob. 56PCh. 1 - Prob. 57PCh. 1 - Prob. 58PCh. 1 - Prob. 59PCh. 1 - Prob. 60PCh. 1 - Which temperature in each pair is higher? a....Ch. 1 - Prob. 62PCh. 1 - Prob. 63PCh. 1 - Draw a graduated cylinder similar to Problem 1.63...Ch. 1 - The given beaker contains 100 mL of water. Draw an...Ch. 1 - Prob. 66PCh. 1 - Prob. 67PCh. 1 - Prob. 68PCh. 1 - If milk has a density of 1.03 g/mL, what is the...Ch. 1 - Prob. 70PCh. 1 - Prob. 71PCh. 1 - Prob. 72PCh. 1 - A lab test showed an individual’s chloesterol leve...Ch. 1 - Hemoglobin is a protein that transports oxygen...Ch. 1 - Prob. 75PCh. 1 - A soccer weighed 70.7 kg before a match, drank 1.8...Ch. 1 - Liposuction is a cosmetic procedure used to remove...Ch. 1 - A single 1-oz serving of tortilla chips contains...Ch. 1 - Prob. 79PCh. 1 - Prob. 80PCh. 1 - Prob. 81PCh. 1 - Prob. 82PCh. 1 - Prob. 83PCh. 1 - Prob. 84PCh. 1 - Often the specific amount of a drug to be...Ch. 1 - Prob. 86CPCh. 1 - Prob. 87CPCh. 1 - Prob. 88CPCh. 1 - Prob. 89CPCh. 1 - Prob. 90CPCh. 1 - Prob. 91CPCh. 1 - If the proper dosage of a medication is 10g/kg of...
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