To propose: A mechanism for the inhibition of CK-B translation in the U937D cells. Introduction: Eukaryotic mRNAs have long 3 ′ UTR that often contains consensus sequences. CK-B is an important enzyme in the cellular metabolism . U937D are cells that have lots of CK-B mRNAs but no CK-B enzyme. In such cells, the CK-B mRNA 5 ′ end is bound to ribosomes but mRNA is not translated.

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Answer 1

Question

Chapter 17.5, Problem 31CQ

Summary Introduction

To propose:

A mechanism for the inhibition of CK-B translation in the U937D cells.

Introduction:

Eukaryotic mRNAs have long 3′ UTR that often contains consensus sequences. CK-B is an important enzyme in the cellular metabolism. U937D are cells that have lots of CK-BmRNAs but no CK-B enzyme. In such cells, the CK-BmRNA5′ end is bound to ribosomes but mRNA is not translated.

Summary Introduction

To explain:

The way in which introduction of short segments of RNA containing the 3’ UTR sequences that might remove that inhibition.

Introduction:

Researchers have introduced numerous short RNA segments containing 3′ UTR sequences only into U937D cells. As a result, these cells began to synthesize CK-B but this does not affect the CK-B mRNA amount. The introduction of short segments did not stimulate the CK-B synthesis, only the 3′ UTR sequences turned on the enzyme translation.

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Answer 2

Question

Chapter 17.5, Problem 31CQ

Summary Introduction

To propose:

A mechanism for the inhibition of CK-B translation in the U937D cells.

Introduction:

Eukaryotic mRNAs have long 3′ UTR that often contains consensus sequences. CK-B is an important enzyme in the cellular metabolism. U937D are cells that have lots of CK-BmRNAs but no CK-B enzyme. In such cells, the CK-BmRNA5′ end is bound to ribosomes but mRNA is not translated.

Summary Introduction

To explain:

The way in which introduction of short segments of RNA containing the 3’ UTR sequences that might remove that inhibition.

Introduction:

Researchers have introduced numerous short RNA segments containing 3′ UTR sequences only into U937D cells. As a result, these cells began to synthesize CK-B but this does not affect the CK-B mRNA amount. The introduction of short segments did not stimulate the CK-B synthesis, only the 3′ UTR sequences turned on the enzyme translation.

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Answer 3

Question

Chapter 17.5, Problem 31CQ

Summary Introduction

To propose:

A mechanism for the inhibition of CK-B translation in the U937D cells.

Introduction:

Eukaryotic mRNAs have long 3′ UTR that often contains consensus sequences. CK-B is an important enzyme in the cellular metabolism. U937D are cells that have lots of CK-BmRNAs but no CK-B enzyme. In such cells, the CK-BmRNA5′ end is bound to ribosomes but mRNA is not translated.

Summary Introduction

To explain:

The way in which introduction of short segments of RNA containing the 3’ UTR sequences that might remove that inhibition.

Introduction:

Researchers have introduced numerous short RNA segments containing 3′ UTR sequences only into U937D cells. As a result, these cells began to synthesize CK-B but this does not affect the CK-B mRNA amount. The introduction of short segments did not stimulate the CK-B synthesis, only the 3′ UTR sequences turned on the enzyme translation.

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Answer 4

Question

Chapter 17.5, Problem 31CQ

Summary Introduction

To propose:

A mechanism for the inhibition of CK-B translation in the U937D cells.

Introduction:

Eukaryotic mRNAs have long 3′ UTR that often contains consensus sequences. CK-B is an important enzyme in the cellular metabolism. U937D are cells that have lots of CK-BmRNAs but no CK-B enzyme. In such cells, the CK-BmRNA5′ end is bound to ribosomes but mRNA is not translated.

Summary Introduction

To explain:

The way in which introduction of short segments of RNA containing the 3’ UTR sequences that might remove that inhibition.

Introduction:

Researchers have introduced numerous short RNA segments containing 3′ UTR sequences only into U937D cells. As a result, these cells began to synthesize CK-B but this does not affect the CK-B mRNA amount. The introduction of short segments did not stimulate the CK-B synthesis, only the 3′ UTR sequences turned on the enzyme translation.

Expert Solution & Answer

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Answer 5

Chapter 17.5, Problem 31CQ

Summary Introduction

To propose:

A mechanism for the inhibition of CK-B translation in the U937D cells.

Introduction:

Eukaryotic mRNAs have long 3′ UTR that often contains consensus sequences. CK-B is an important enzyme in the cellular metabolism. U937D are cells that have lots of CK-BmRNAs but no CK-B enzyme. In such cells, the CK-BmRNA5′ end is bound to ribosomes but mRNA is not translated.

Summary Introduction

To explain:

The way in which introduction of short segments of RNA containing the 3’ UTR sequences that might remove that inhibition.

Introduction:

Researchers have introduced numerous short RNA segments containing 3′ UTR sequences only into U937D cells. As a result, these cells began to synthesize CK-B but this does not affect the CK-B mRNA amount. The introduction of short segments did not stimulate the CK-B synthesis, only the 3′ UTR sequences turned on the enzyme translation.

Answer 6

Chapter 17.5, Problem 31CQ

Summary Introduction

To propose:

A mechanism for the inhibition of CK-B translation in the U937D cells.

Introduction:

Eukaryotic mRNAs have long 3′ UTR that often contains consensus sequences. CK-B is an important enzyme in the cellular metabolism. U937D are cells that have lots of CK-BmRNAs but no CK-B enzyme. In such cells, the CK-BmRNA5′ end is bound to ribosomes but mRNA is not translated.

Answer 7

Chapter 17.5, Problem 31CQ

Summary Introduction

To propose:

A mechanism for the inhibition of CK-B translation in the U937D cells.

Introduction:

Eukaryotic mRNAs have long 3′ UTR that often contains consensus sequences. CK-B is an important enzyme in the cellular metabolism. U937D are cells that have lots of CK-BmRNAs but no CK-B enzyme. In such cells, the CK-BmRNA5′ end is bound to ribosomes but mRNA is not translated.

Answer 8

Summary Introduction

To explain:

The way in which introduction of short segments of RNA containing the 3’ UTR sequences that might remove that inhibition.

Introduction:

Researchers have introduced numerous short RNA segments containing 3′ UTR sequences only into U937D cells. As a result, these cells began to synthesize CK-B but this does not affect the CK-B mRNA amount. The introduction of short segments did not stimulate the CK-B synthesis, only the 3′ UTR sequences turned on the enzyme translation.

Answer 9

Summary Introduction

To explain:

The way in which introduction of short segments of RNA containing the 3’ UTR sequences that might remove that inhibition.

Introduction:

Researchers have introduced numerous short RNA segments containing 3′ UTR sequences only into U937D cells. As a result, these cells began to synthesize CK-B but this does not affect the CK-B mRNA amount. The introduction of short segments did not stimulate the CK-B synthesis, only the 3′ UTR sequences turned on the enzyme translation.

Answer 10

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Answer 11

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Answer 13

Ch. 17.1 - Prob. 2COQ Ch. 17.2 - Prob. 15AQP Ch. 17.2 - Prob. 16AQP Ch. 17.2 - Prob. 17AQP Ch. 17.2 - Prob. 18AQP Ch. 17.2 - Prob. 19AQP Ch. 17.2 - Prob. 1CC Ch. 17.2 - Prob. 3COQ Ch. 17.2 - Prob. 4COQ Ch. 17.2 - Prob. 5COQ

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Chapter 17 Solutions