Human Anatomy & Physiology, Books a la Carte Edition (2nd Edition)
2nd Edition
ISBN: 9780134754239
Author: Erin C. Amerman
Publisher: PEARSON
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Textbook Question
Chapter 17.4, Problem 4QC
Is the end-diastolic or the end-systolic volume of blood larger? Why?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 17 Solutions
Human Anatomy & Physiology, Books a la Carte Edition (2nd Edition)
Ch. 17.1 - Where is the heart located, and how large is it?Ch. 17.1 - What are the hearts upper and lower chambers...Ch. 17.1 - What are the sources from which blood flows into...Ch. 17.1 - 4. Which side of the heart is considered the...Ch. 17.1 - Which side of the heart is considered the systemic...Ch. 17.2 - Prob. 1QCCh. 17.2 - Prob. 2QCCh. 17.2 - 3. What are the three layers of the heart wall,...Ch. 17.2 - 4. What are the four main great vessels? From...Ch. 17.2 - How do the right and left ventricles differ in...
Ch. 17.2 - 6. Why do you think it is important to ensure via...Ch. 17.2 - 7. What is the overall pathway of blood flow...Ch. 17.2 - Prob. 8QCCh. 17.2 - Prob. 9QCCh. 17.2 - Prob. 10QCCh. 17.3 - How do pacemaker and contractile cells differ?...Ch. 17.3 - 2. What are intercalated discs? What is their...Ch. 17.3 - Prob. 3QCCh. 17.3 - Prob. 4QCCh. 17.3 - What is the sequence of events of a contractile...Ch. 17.3 - How does the refractory period of cardiac muscle...Ch. 17.3 - 7. What does an ECG record?
Ch. 17.3 - What are the five waves in an ECG, and what do...Ch. 17.4 - What causes the heart sounds S1 and S2?Ch. 17.4 - Prob. 2QCCh. 17.4 - Prob. 3QCCh. 17.4 - Is the end-diastolic or the end-systolic volume of...Ch. 17.4 - 5. Walk through the mechanical events of the...Ch. 17.4 - 6. Relate the ECG waves to the cardiac cycle...Ch. 17.4 - 7. How does the left ventricular pressure...Ch. 17.5 - Prob. 1QCCh. 17.5 - What is cardiac output? How does it relate to...Ch. 17.5 - Prob. 3QCCh. 17.5 - What is the Frank-Starling law, and how does it...Ch. 17.5 - What is a chronotropic agent?Ch. 17.5 - Prob. 6QCCh. 17.5 - 7. What effects does the parasympathetic nervous...Ch. 17.5 - How would a hormone that decreases the amount of...Ch. 17.5 - How is heart failure defined?Ch. 17 - 1. Mark the following statements as true or false....Ch. 17 - 2. The pericardial cavity is located between:
a....Ch. 17 - 3. Which of the following statements is true?
a....Ch. 17 - Match the following terms with the correct...Ch. 17 - Fill in the blanks: The coronary arteries are the...Ch. 17 - 6. How do pacemaker cardiac muscle cells differ...Ch. 17 - 7. Cardiac muscle cells are joined by structures...Ch. 17 - Prob. 8CYRCh. 17 - Prob. 9CYRCh. 17 - 10. The _________is the primary pacemaker of the...Ch. 17 - The AV node delay: a. allows the atria and...Ch. 17 - Explain what each of the following terms...Ch. 17 - 13. Mark the following statements as true or...Ch. 17 - Prob. 14CYRCh. 17 - 15. Fill in the blanks: The first heart sound is...Ch. 17 - Cardiac output is equal to: a. end-diastolic...Ch. 17 - Prob. 17CYRCh. 17 - 18. Which of the following statements is false?
a....Ch. 17 - 1. A birth defect called transposition of great...Ch. 17 - 2. Predict which would be more damaging to...Ch. 17 - 3. When the SA node doesn’t function properly, the...Ch. 17 - Prob. 4CYUCh. 17 - Prob. 1AYKACh. 17 - Prob. 2AYKACh. 17 - Prob. 3AYKACh. 17 - Prob. 4AYKB
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