Human Anatomy & Physiology, Books a la Carte Edition (2nd Edition)
2nd Edition
ISBN: 9780134754239
Author: Erin C. Amerman
Publisher: PEARSON
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Chapter 17, Problem 10CYR
The _________is the primary pacemaker of the heart.
a. atrioventricular node
b. sinoatrial node
c. Purkinje fiber system
d. atrioventricular bundle
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 17 Solutions
Human Anatomy & Physiology, Books a la Carte Edition (2nd Edition)
Ch. 17.1 - Where is the heart located, and how large is it?Ch. 17.1 - What are the hearts upper and lower chambers...Ch. 17.1 - What are the sources from which blood flows into...Ch. 17.1 - 4. Which side of the heart is considered the...Ch. 17.1 - Which side of the heart is considered the systemic...Ch. 17.2 - Prob. 1QCCh. 17.2 - Prob. 2QCCh. 17.2 - 3. What are the three layers of the heart wall,...Ch. 17.2 - 4. What are the four main great vessels? From...Ch. 17.2 - How do the right and left ventricles differ in...
Ch. 17.2 - 6. Why do you think it is important to ensure via...Ch. 17.2 - 7. What is the overall pathway of blood flow...Ch. 17.2 - Prob. 8QCCh. 17.2 - Prob. 9QCCh. 17.2 - Prob. 10QCCh. 17.3 - How do pacemaker and contractile cells differ?...Ch. 17.3 - 2. What are intercalated discs? What is their...Ch. 17.3 - Prob. 3QCCh. 17.3 - Prob. 4QCCh. 17.3 - What is the sequence of events of a contractile...Ch. 17.3 - How does the refractory period of cardiac muscle...Ch. 17.3 - 7. What does an ECG record?
Ch. 17.3 - What are the five waves in an ECG, and what do...Ch. 17.4 - What causes the heart sounds S1 and S2?Ch. 17.4 - Prob. 2QCCh. 17.4 - Prob. 3QCCh. 17.4 - Is the end-diastolic or the end-systolic volume of...Ch. 17.4 - 5. Walk through the mechanical events of the...Ch. 17.4 - 6. Relate the ECG waves to the cardiac cycle...Ch. 17.4 - 7. How does the left ventricular pressure...Ch. 17.5 - Prob. 1QCCh. 17.5 - What is cardiac output? How does it relate to...Ch. 17.5 - Prob. 3QCCh. 17.5 - What is the Frank-Starling law, and how does it...Ch. 17.5 - What is a chronotropic agent?Ch. 17.5 - Prob. 6QCCh. 17.5 - 7. What effects does the parasympathetic nervous...Ch. 17.5 - How would a hormone that decreases the amount of...Ch. 17.5 - How is heart failure defined?Ch. 17 - 1. Mark the following statements as true or false....Ch. 17 - 2. The pericardial cavity is located between:
a....Ch. 17 - 3. Which of the following statements is true?
a....Ch. 17 - Match the following terms with the correct...Ch. 17 - Fill in the blanks: The coronary arteries are the...Ch. 17 - 6. How do pacemaker cardiac muscle cells differ...Ch. 17 - 7. Cardiac muscle cells are joined by structures...Ch. 17 - Prob. 8CYRCh. 17 - Prob. 9CYRCh. 17 - 10. The _________is the primary pacemaker of the...Ch. 17 - The AV node delay: a. allows the atria and...Ch. 17 - Explain what each of the following terms...Ch. 17 - 13. Mark the following statements as true or...Ch. 17 - Prob. 14CYRCh. 17 - 15. Fill in the blanks: The first heart sound is...Ch. 17 - Cardiac output is equal to: a. end-diastolic...Ch. 17 - Prob. 17CYRCh. 17 - 18. Which of the following statements is false?
a....Ch. 17 - 1. A birth defect called transposition of great...Ch. 17 - 2. Predict which would be more damaging to...Ch. 17 - 3. When the SA node doesn’t function properly, the...Ch. 17 - Prob. 4CYUCh. 17 - Prob. 1AYKACh. 17 - Prob. 2AYKACh. 17 - Prob. 3AYKACh. 17 - Prob. 4AYKB
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