Local hormones are a huge group of signaling molecules. These are released from the cells which produce them or are secreted from neighboring cells. Eicosanoid is a primary type of local hormone which is released from fatty acids. It is formed by an enzymatic cascade. It causes the stimulation of cells that produced it (autocrine stimulation) or its neighboring cells (paracrine stimulation). Leukotrienes from damaged tissue cause smooth muscle in local blood vessels to vasodilate or increase the vessel lumen.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

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Chapter 17.3, Problem 8WDL

Summary Introduction

Introduction:

Local hormones are a huge group of signaling molecules. These are released from the cells which produce them or are secreted from neighboring cells. Eicosanoid is a primary type of local hormone which is released from fatty acids. It is formed by an enzymatic cascade. It causes the stimulation of cells that produced it (autocrine stimulation) or its neighboring cells (paracrine stimulation). Leukotrienes from damaged tissue cause smooth muscle in local blood vessels to vasodilate or increase the vessel lumen.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

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