LIFE: THE SCIENCE OF BIOLOGY
LIFE: THE SCIENCE OF BIOLOGY
11th Edition
ISBN: 9781319145125
Author: Sadava
Publisher: MAC HIGHER
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Chapter 17.3, Problem 2R
Summary Introduction

To review:

The evolutionary importance of gene families

Introduction:

The prokaryotic genome is small and compact as it contains only protein-coding genes but, the eukaryotic genome is large and complex as it contains a coding region, noncoding region, and regulatory sequences. The prokaryotic genome is haploid while half of all protein-coding genes of eukaryotes have a single copy and other protein-coding genes have multiple copies. Gene duplications have resulted in multiple copies of the same gene and because of separate mutation in different gene copies, gene families arise.

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
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