
Concept explainers
To review:
The relationship between genotype of patients and concentration as well as
Given:
In the given study, the drug calm was administered to people whose SNPs were known and after 12 hours, blood samples were drawn to find the concentration of the drug. The three different SNPs with genotypes are: SNP 5689 (AA, AG, and GG), SNP 8835 (AA, AC, and CC), and SNP 11286 (TT, TG, and GG) as shown in Figure below. The letters (A, T, G, and C) stand for the type of nucleotide on the two homologous chromosomes.
Introduction:
The study of effectiveness of the drug based on information about individual genome or SNPs is called pharmacogenomics. The metabolism of calm depends on the genotype or SNP present in each individual.

Explanation of Solution
SNP 5869: The rate of metabolism and drug concentration after 12 hours of administration is correlated with different genotypes of SNP 5869. The metabolism of the drug is efficient in the people with genotype GG where the drug concentration in the blood is around 70. On the other hand, the drug concentration for the genotype AG is around 100 and it is around 130 for AA genotype. So, the genotype GG of SNP 5869 is associated with metabolizing the drug, calm efficiently.
SNP 8835: The rate of metabolism is high in the case of the genotype AA where the drug concentration is less, which is around 80. On the other hand, the rate of drug metabolism is less in the case of the genotype CC with drug concentration of around 120 and genotype AC where the concentration is around 100. So, the genotype AA of SNP 8835 is associated with metabolizing the drug, calm efficiently.
SNP 11286: The rate of metabolism is efficient for the genotype TT where the drug concentration is around 80. The rate of metabolism is less for the genotypes GG and TG where the drug concentration is 90 and 110, respectively. So, the genotype TT of SNP 11286 is associated with metabolizing the drug, calm efficiently.
Thus, efficiency and rate of drug metabolism depend on the genotypes where drug concentration is inversely proportional to the rate of metabolism.
Want to see more full solutions like this?
Chapter 17 Solutions
LIFE: THE SCIENCE OF BIOLOGY
- What is a gain of function mutation?arrow_forwardMolecular Biology Question: Please help. Thank you Is Southern hybridization's purpose detecting specific nucleotide sequences? How so?arrow_forwardUse the following information to answer the question(s) below. Martin Wikelski and L. Michael Romero (Body size, performance and fitness in Galápagos marine iguanas, Integrative and Comparative Biology 43 [2003]:376-86) measured the snout-to-vent (anus) length of Galápagos marine iguanas and observed the percent survival of different-sized animals, all of the same age. The graph shows the log snout-vent length (SVL, a measure of overall body size) plotted against the percent survival of these different size classes for males and females. Survival (%) 100- 80- 60- 40- 20- 0+ 1.9 T 2 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Log SVL (mm) 19) Examine the figure above. What type of selection for body size appears to be occurring in these marine iguanas? A) directional selection B) stabilizing selection C) disruptive selection D) You cannot determine the type of selection from the above information. 3arrow_forward
- 24) Use the following information to answer the question below. Researchers studying a small milkweed population note that some plants produce a toxin and other plants do not. They identify the gene responsible for toxin production. The dominant allele (T) codes for an enzyme that makes the toxin, and the recessive allele (t) codes for a nonfunctional enzyme that cannot produce the toxin. Heterozygotes produce an intermediate amount of toxin. The genotypes of all individuals in the population are determined (see table) and used to determine the actual allele frequencies in the population. TT 0.49 Tt 0.42 tt 0.09 Refer to the table above. Is this population in Hardy-Weinberg equilibrium? A) Yes. C) No; there are more homozygotes than expected. B) No; there are more heterozygotes than expected. D) It is impossible to tell.arrow_forward30) A B CDEFG Refer to the accompanying figure. Which of the following forms a monophyletic group? A) A, B, C, and D B) C and D C) D, E, and F D) E, F, and Garrow_forwardMolecular Biology Question. Please help with step solution and explanation. Thank you: The Polymerase Chain Reaction (PCR) reaction consists of three steps denaturation, hybridization, and elongation. Please describe what occurs in the annealing step of the PCR reaction. (I think annealing step is hybridization). What are the other two steps of PCR, and what are their functions? Next, suppose the Tm for the two primers being used are 54C for Primer A and 67C for Primer B. Regarding annealing step temperature, I have the following choices for the temperature used during the annealing step:(a) 43C (b) 49C (c) 62C (d) 73C Which temperature/temperatures should I choose? What is the corresponding correct explanation, and why would I not use the other temperatures? Have a good day!arrow_forward
- Using the data provided on the mean body mass and horn size of 4-year-old male sheep, draw a scatterplot graph to examine how body mass and horn size changed over time.arrow_forwardPlease write a 500-word report about the intake of saturated fat, sodium, alcoholic beverages, or added sugar in America. Choose ONE of these and write about what is recommended by the Dietary Guidelines for Americans (guideline #4) and why Americans exceed the intake of that nutrient. Explain what we could do as a society and/or individuals to reduce our intake of your chosen nutrient.arrow_forwardWrite a 500-word report indicating how you can change the quantity or quality of TWO nutrients where your intake was LOWER than what is recommended by the Dietary Guidelines for Americans and/or the DRIs. Indicate how the lack of the nutrient may affect your health. For full credit, all of the following points must be addressed and elaborated on in more detail for each nutrient: The name of the nutrient At least 2 main functions of the nutrient (example: “Vitamin D regulates calcium levels in the blood and calcification of bones.”) Your percent intake compared to the RDA/DRI (example “I consumed 50% of the RDA for vitamin D”) Indicate why your intake was below the recommendations (example: “I only had one serving of dairy products and that was why I was below the recommendations for vitamin D”) How would you change your dietary pattern to meet the recommendations? – be sure to list specific foods (example: “I would add a yogurt and a glass of milk to each day in order to increase my…arrow_forward
- Why are nutrient absorption and dosage levels important when taking multivitamins and vitamin and mineral supplements?arrow_forwardI'm struggling with this topic and would really appreciate your help. I need to hand-draw a diagram and explain the process of sexual differentiation in humans, including structures, hormones, enzymes, and other details. Could you also make sure to include these terms in the explanation? . Gonads . Wolffian ducts • Müllerian ducts . ⚫ Testes . Testosterone • Anti-Müllerian Hormone (AMH) . Epididymis • Vas deferens ⚫ Seminal vesicles ⚫ 5-alpha reductase ⚫ DHT - Penis . Scrotum . Ovaries • Uterus ⚫ Fallopian tubes - Vagina - Clitoris . Labia Thank you so much for your help!arrow_forwardRequisition Exercise A phlebotomist goes to a patient’s room with the following requisition. Hometown Hospital USA 125 Goodcare Avenue Small Town, USAarrow_forward
- Biology Today and Tomorrow without Physiology (Mi...BiologyISBN:9781305117396Author:Cecie Starr, Christine Evers, Lisa StarrPublisher:Cengage Learning
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage LearningConcepts of BiologyBiologyISBN:9781938168116Author:Samantha Fowler, Rebecca Roush, James WisePublisher:OpenStax College


