Pearson eText Human Physiology: An Integrated Approach -- Instant Access (Pearson+)
8th Edition
ISBN: 9780135212905
Author: Dee Silverthorn
Publisher: PEARSON+
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Textbook Question
Chapter 17, Problem 9RQ
During inspiration, most of the thoracic volume change is the result of movement of the _____.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 17 Solutions
Pearson eText Human Physiology: An Integrated Approach -- Instant Access (Pearson+)
Ch. 17.1 - What is the difference between cellular...Ch. 17.1 - Prob. 2CCCh. 17.1 - Name the components (including muscles) of the...Ch. 17.1 - Which air passages of the respiratory system are...Ch. 17.1 - Cigarette smoking paralyzes cilia in the airways...Ch. 17.1 - Is blood flow through the pulmonary trunk greater...Ch. 17.1 - A person has left ventricular failure but normal...Ch. 17.1 - Calculate the mean pressure in a person whose...Ch. 17.2 - If nitrogen is 78% of atmospheric air, what is the...Ch. 17.2 - The partial pressure of water vapor in inspired...
Ch. 17.3 - How are lung volumes related to lung capacities?Ch. 17.3 - Which lung volume cannot be measured directly?Ch. 17.3 - Prob. 13CCCh. 17.3 - As inhaled air becomes humidified passing down the...Ch. 17.3 - Compare the direction of air movement during one...Ch. 17.3 - Explain the relationship between the lungs, the...Ch. 17.3 - Scarlett OHara is trying to squeeze herself into a...Ch. 17.3 - Why would loss of the ability to cough increase...Ch. 17.3 - Prob. 19CCCh. 17.3 - A stabbing victim is brought to the emergency room...Ch. 17.3 - In a normal person, which contributes more to the...Ch. 17.3 - Coal miners who spend years inhaling fine coal...Ch. 17.3 - How does the work required for breathing change...Ch. 17.3 - A cancerous lung tumor has grown into the walls of...Ch. 17.3 - Prob. 25CCCh. 17.3 - Prob. 26CCCh. 17.3 - Restrictive lung diseases decrease lung...Ch. 17.3 - Chronic obstructive lung disease causes patients...Ch. 17 - List four functions of the respiratory system.Ch. 17 - Give two definitions for the word respiration.Ch. 17 - Which sets of muscles are used for normal quiet...Ch. 17 - Give two functions of pleural fluid.Ch. 17 - Name the anatomical structures that an oxygen...Ch. 17 - Diagram the structure of an alveolus, and state...Ch. 17 - Trace the path of the pulmonary circulation. About...Ch. 17 - What happens to inspired air as it is conditioned...Ch. 17 - During inspiration, most of the thoracic volume...Ch. 17 - Prob. 10RQCh. 17 - Refer to the spirogram in the following figure: a....Ch. 17 - Of the three factors that contribute to the...Ch. 17 - Prob. 13RQCh. 17 - What is the function of surfactants in general? In...Ch. 17 - Prob. 15RQCh. 17 - Prob. 16RQCh. 17 - Prob. 17RQCh. 17 - Compile the following terms into a map of...Ch. 17 - Decide whether each of the following parameters...Ch. 17 - Prob. 20RQCh. 17 - The cartoon coyote is blowing up a balloon in...Ch. 17 - Match the descriptions to the appropriate phase(s)...Ch. 17 - Draw and label a graph showing the PO2 of air in...Ch. 17 - Prob. 24RQCh. 17 - Prob. 25RQCh. 17 - A student breathes at a rate of 20 breaths/min,...Ch. 17 - Prob. 27RQCh. 17 - Prob. 28RQCh. 17 - Assume a normal female has a resting tidal volume...Ch. 17 - Prob. 30RQCh. 17 - Prob. 31RQCh. 17 - Prob. 32RQCh. 17 - Prob. 33RQCh. 17 - Prob. 34RQCh. 17 - Prob. 35RQCh. 17 - Prob. 36RQ
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