Human Physiology
15th Edition
ISBN: 9781259864629
Author: Fox, Stuart Ira
Publisher: Mcgraw-hill Education,
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Chapter 17, Problem 39RA
Summary Introduction
To review:
The glomerular filtration rate (GFR) in the provided case.
Introduction:
The task of filtration of blood and maintaining the fluid balance in the body is carried out by the renal system. It also helps in the urine formation by filtering the excess materials and water from the blood. The nephrons in both the kidneys are associated with the filtration of blood.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 17 Solutions
Human Physiology
Ch. 17 - Describe the "theme" of kidney function in a...Ch. 17 - Draw and label the tubular components of a nephron...Ch. 17 - Trace the course of tubular fluid from the...Ch. 17 - Trace the course of blood flow through the kidney...Ch. 17 - Describe the structures that plasma fluid must...Ch. 17 - Describe the forces that affect the formation of...Ch. 17 - Explain the significance of the glomerular...Ch. 17 - Prob. 5bCPCh. 17 - Describe the mechanisms for salt and water...Ch. 17 - Compare the transport of and water across the...
Ch. 17 - Describe the interaction between the ascending and...Ch. 17 - Explain how ADH helps the body conserve water. How...Ch. 17 - Define renal plasma clearance and describe how...Ch. 17 - Define the terms reabsorption and secretion. Using...Ch. 17 - Explain why the total renal blood flow can be...Ch. 17 - Define transport maximum and renal plasma...Ch. 17 - Describe the effects of aldosterone on the renal...Ch. 17 - Prob. 11bCPCh. 17 - Explain the mechanisms by which the cortical...Ch. 17 - Explain how the kidneys reabsorb filtered...Ch. 17 - Suppose a person with diabetes mellitus had an...Ch. 17 - List the different categories of clinical...Ch. 17 - Explain why most diuretics can cause excessive...Ch. 17 - Define uremia and discuss the dangers associated...Ch. 17 - Which of these statements about the renal pyramids...Ch. 17 - Match the following items:
Active transport of...Ch. 17 - Match the following items:
Active transport of...Ch. 17 - Match the following items:
Passively permeable to...Ch. 17 - Match the following items:
Passively permeable to...Ch. 17 - Antidiuretic hormone promotes the retention of...Ch. 17 - Aldosterone stimulates sodium reabsorption and...Ch. 17 - Substance X has a clearance greater than zero but...Ch. 17 - Prob. 9RACh. 17 - About of the glomerular ultrafiltrate is...Ch. 17 - Diuretic drugs that act in the nephron loop...Ch. 17 - The appearance of glucose in the urine a. occurs...Ch. 17 - Reabsorption of water through the tubules occurs...Ch. 17 - Which of these factors oppose(s) filtration from...Ch. 17 - The countercurrent exchange in the vasa recta...Ch. 17 - The kidneys help to maintain acid-base balance...Ch. 17 - Scientists currently believe that the main barrier...Ch. 17 - A drug that blocks the action of the organic anion...Ch. 17 - Explain how glomerular ultra filtrate is produced...Ch. 17 - Describe the transport properties of the nephron...Ch. 17 - Prob. 21RACh. 17 - Prob. 22RACh. 17 - Prob. 23RACh. 17 - Prob. 24RACh. 17 - Identify where secretion occurs in the nephron,...Ch. 17 - Which diuretic drugs do not produce hypokalemia?...Ch. 17 - Prob. 27RACh. 17 - Prob. 28RACh. 17 - Prob. 29RACh. 17 - Prob. 30RACh. 17 - Prob. 31RACh. 17 - Prob. 32RACh. 17 - s Suppose a woman with a family history of...Ch. 17 - Prob. 34RACh. 17 - Prob. 35RACh. 17 - Prob. 36RACh. 17 - Prob. 37RACh. 17 - Prob. 38RACh. 17 - Prob. 39RACh. 17 - Prob. 40RACh. 17 - Prob. 41RACh. 17 - Prob. 42RA
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