HUMAN PHYSIO W/ APR & PHILS (LL) PKG
15th Edition
ISBN: 9781265382353
Author: Fox
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 17, Problem 25RA
Identify where
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Molecular Biology
A-C components of the question are corresponding to attached image labeled 1.
D component of the question is corresponding to attached image labeled 2.
For a eukaryotic mRNA, the sequences is as follows where AUGrepresents the start codon, the yellow is the Kozak sequence and (XXX) just represents any codonfor an amino acid (no stop codons here). G-cap and polyA tail are not shown
A. How long is the peptide produced?B. What is the function (a sentence) of the UAA highlighted in blue?C. If the sequence highlighted in blue were changed from UAA to UAG, how would that affecttranslation?
D. (1) The sequence highlighted in yellow above is moved to a new position indicated below. Howwould that affect translation? (2) How long would be the protein produced from this new mRNA?
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Explain why the cell doesn’t need 61 tRNAs (one for each codon).
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You discover a disease causing mutation (indicated by the arrow) that alters splicing of its mRNA. This mutation (a base substitution in the splicing sequence) eliminates a 3’ splice site resulting in the inclusion of the second intron (I2) in the final mRNA. We are going to pretend that this intron is short having only 15 nucleotides (most introns are much longer so this is just to make things simple) with the following sequence shown below in bold. The ( ) indicate the reading frames in the exons; the included intron 2 sequences are in bold.
A. Would you expected this change to be harmful? ExplainB. If you were to do gene therapy to fix this problem, briefly explain what type of gene therapy youwould use to correct this.
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Chapter 17 Solutions
HUMAN PHYSIO W/ APR & PHILS (LL) PKG
Ch. 17 - Describe the "theme" of kidney function in a...Ch. 17 - Draw and label the tubular components of a nephron...Ch. 17 - Trace the course of tubular fluid from the...Ch. 17 - Trace the course of blood flow through the kidney...Ch. 17 - Describe the structures that plasma fluid must...Ch. 17 - Describe the forces that affect the formation of...Ch. 17 - Explain the significance of the glomerular...Ch. 17 - Prob. 5bCPCh. 17 - Describe the mechanisms for salt and water...Ch. 17 - Compare the transport of and water across the...
Ch. 17 - Describe the interaction between the ascending and...Ch. 17 - Explain how ADH helps the body conserve water. How...Ch. 17 - Define renal plasma clearance and describe how...Ch. 17 - Define the terms reabsorption and secretion. Using...Ch. 17 - Explain why the total renal blood flow can be...Ch. 17 - Define transport maximum and renal plasma...Ch. 17 - Describe the effects of aldosterone on the renal...Ch. 17 - Prob. 11bCPCh. 17 - Explain the mechanisms by which the cortical...Ch. 17 - Explain how the kidneys reabsorb filtered...Ch. 17 - Suppose a person with diabetes mellitus had an...Ch. 17 - List the different categories of clinical...Ch. 17 - Explain why most diuretics can cause excessive...Ch. 17 - Define uremia and discuss the dangers associated...Ch. 17 - Which of these statements about the renal pyramids...Ch. 17 - Match the following items:
Active transport of...Ch. 17 - Match the following items:
Active transport of...Ch. 17 - Match the following items:
Passively permeable to...Ch. 17 - Match the following items:
Passively permeable to...Ch. 17 - Antidiuretic hormone promotes the retention of...Ch. 17 - Aldosterone stimulates sodium reabsorption and...Ch. 17 - Substance X has a clearance greater than zero but...Ch. 17 - Prob. 9RACh. 17 - About of the glomerular ultrafiltrate is...Ch. 17 - Diuretic drugs that act in the nephron loop...Ch. 17 - The appearance of glucose in the urine a. occurs...Ch. 17 - Reabsorption of water through the tubules occurs...Ch. 17 - Which of these factors oppose(s) filtration from...Ch. 17 - The countercurrent exchange in the vasa recta...Ch. 17 - The kidneys help to maintain acid-base balance...Ch. 17 - Scientists currently believe that the main barrier...Ch. 17 - A drug that blocks the action of the organic anion...Ch. 17 - Explain how glomerular ultra filtrate is produced...Ch. 17 - Describe the transport properties of the nephron...Ch. 17 - Prob. 21RACh. 17 - Prob. 22RACh. 17 - Prob. 23RACh. 17 - Prob. 24RACh. 17 - Identify where secretion occurs in the nephron,...Ch. 17 - Which diuretic drugs do not produce hypokalemia?...Ch. 17 - Prob. 27RACh. 17 - Prob. 28RACh. 17 - Prob. 29RACh. 17 - Prob. 30RACh. 17 - Prob. 31RACh. 17 - Prob. 32RACh. 17 - s Suppose a woman with a family history of...Ch. 17 - Prob. 34RACh. 17 - Prob. 35RACh. 17 - Prob. 36RACh. 17 - Prob. 37RACh. 17 - Prob. 38RACh. 17 - Prob. 39RACh. 17 - Prob. 40RACh. 17 - Prob. 41RACh. 17 - Prob. 42RA
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