Hole's Essentials of Human Anatomy & Physiology
13th Edition
ISBN: 9781259277368
Author: David N. Shier Dr., Jackie L. Butler, Ricki Lewis Dr.
Publisher: McGraw-Hill Education
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Chapter 17, Problem 25CA
Summary Introduction
To compare: The processes that reabsorb urea and uric acid.
Introduction: Reabsorption, also known as tubular reabsorption, is the mechanism by which the nephron eliminates solutes and water from the tubular fluid and also returns them to the circulating blood. Urea is filtered freely; in the proximal convoluted tubule, 50% is reabsorbed with the reabsorption of water.
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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.
b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake?
Options:
A. Dose; Increase dose
B. Dose; Decrease dose
C. Dose; Do not change dose
D. Interval; Increase the interval between doses (give the drug less frequently)
E. Interval; Decrease the interval between doses (give the drug more frequently)
F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
Chapter 17 Solutions
Hole's Essentials of Human Anatomy & Physiology
Ch. 17.1 -
List the general functions of the organs of the...Ch. 17.1 - Prob. 1PCh. 17.2 - Prob. 2LCh. 17.2 - Prob. 3LCh. 17.2 - Prob. 4LCh. 17.2 - Prob. 5LCh. 17.2 - Prob. 2PCh. 17.2 - Prob. 3PCh. 17.2 - Prob. 4PCh. 17.2 - Prob. 5P
Ch. 17.2 - Prob. 6PCh. 17.2 - Prob. 7PCh. 17.2 - Prob. 8PCh. 17.3 - Prob. 6LCh. 17.3 -
Explain the factors that affect the rate of...Ch. 17.3 -
Discuss the role of tubular reabsorption in urine...Ch. 17.3 - Define tubular secretion, and explain its role in...Ch. 17.3 - Vasoconstriction of which arteriole in part (a) of...Ch. 17.3 - Which processes form urine?
Ch. 17.3 - Prob. 10PCh. 17.3 - Which factors influence the rate of glomerular...Ch. 17.3 - What is the function of the macula densa?
Ch. 17.3 - Prob. 13PCh. 17.3 - Which of the three processes (glomerular...Ch. 17.3 - Which chemicals are normally present in the...Ch. 17.3 - Which mechanisms reabsorb solutes from the...Ch. 17.3 - Describe the role of passive transport in urine...Ch. 17.3 - Define tubular secretion.
Ch. 17.3 - Which substances are actively secreted?
Ch. 17.3 - How does sodium reabsorption affect potassium...Ch. 17.3 - How does the hypothalamus regulate urine...Ch. 17.3 - Explain how urea and uric acid are excreted.
Ch. 17.3 - List the normal constituents of urine.
Ch. 17.3 - Which factors affect urine volume?
Ch. 17.4 - Prob. 10LCh. 17.4 - Prob. 11LCh. 17.4 - Prob. 24PCh. 17.4 - Prob. 25PCh. 17.4 - Prob. 26PCh. 17.4 - Prob. 27PCh. 17.4 - Prob. 28PCh. 17.4 - Prob. 29PCh. 17.4 - Prob. 30PCh. 17.4 - Prob. 31PCh. 17.4 - Prob. 32PCh. 17 - Prob. 1CACh. 17 - Prob. 2CACh. 17 - Prob. 3CACh. 17 - Prob. 4CACh. 17 - Prob. 5CACh. 17 - Prob. 6CACh. 17 - Prob. 7CACh. 17 - Prob. 8CACh. 17 - Prob. 9CACh. 17 - Prob. 10CACh. 17 - Prob. 11CACh. 17 - Prob. 12CACh. 17 - Prob. 13CACh. 17 - Prob. 14CACh. 17 - Prob. 15CACh. 17 - Prob. 16CACh. 17 - Prob. 17CACh. 17 - Prob. 18CACh. 17 - Prob. 19CACh. 17 -
Explain how amino acids and proteins are...Ch. 17 - Prob. 21CACh. 17 - Prob. 22CACh. 17 - Prob. 23CACh. 17 - Prob. 24CACh. 17 - Prob. 25CACh. 17 - Prob. 26CACh. 17 - Prob. 27CACh. 17 - Prob. 28CACh. 17 - Prob. 29CACh. 17 - Prob. 30CACh. 17 - Prob. 31CACh. 17 - Prob. 32CACh. 17 - Prob. 33CACh. 17 - Prob. 34CACh. 17 - Prob. 1IACTCh. 17 - Prob. 2IACTCh. 17 - Prob. 3IACTCh. 17 - Prob. 4IACTCh. 17 - Prob. 5IACTCh. 17 - Prob. 6IACT
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