ANATOMY+PHYSIOLOGY >CUSTOM<
9th Edition
ISBN: 2818440061721
Author: SALADIN
Publisher: MCG/CREATE
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Chapter 17, Problem 1TYC
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The steroid hormone produces great
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 17 Solutions
ANATOMY+PHYSIOLOGY >CUSTOM<
Ch. 17.1 - Define the word hormone and distinguish a hormone...Ch. 17.1 - Prob. 2BYGOCh. 17.1 - Prob. 3BYGOCh. 17.1 - Prob. 4BYGOCh. 17.1 - Discuss why the target-cell concept is essential...Ch. 17.1 - The importance of intercellular communication for...Ch. 17.1 - The general term for the cells and glands that...Ch. 17.1 - Prob. 3AYLOCh. 17.1 - Prob. 4AYLOCh. 17.1 - Prob. 5AYLO
Ch. 17.2 - Prob. 6BYGOCh. 17.2 - Prob. 7BYGOCh. 17.2 - Prob. 8BYGOCh. 17.2 - In what sense does the pituitary take orders from...Ch. 17.2 - Prob. 10BYGOCh. 17.2 - Prob. 1AYLOCh. 17.2 - Prob. 2AYLOCh. 17.2 - Prob. 3AYLOCh. 17.2 - Two hormones synthesized in the hypothalamus and...Ch. 17.2 - Prob. 5AYLOCh. 17.2 - Two hormones secreted by the posterior pituitary,...Ch. 17.2 - Prob. 7AYLOCh. 17.2 - Prob. 8AYLOCh. 17.3 - Prob. 11BYGOCh. 17.3 - Prob. 12BYGOCh. 17.3 - Prob. 13BYGOCh. 17.3 - Prob. 14BYGOCh. 17.3 - Prob. 15BYGOCh. 17.3 - Prob. 16BYGOCh. 17.3 - Prob. 1AYLOCh. 17.3 - Prob. 2AYLOCh. 17.3 - Prob. 3AYLOCh. 17.3 - Anatomy of the parathyroid glands; their hormone...Ch. 17.3 - Prob. 5AYLOCh. 17.3 - Prob. 6AYLOCh. 17.3 - Three tissue zones of the adrenal cortex, the...Ch. 17.3 - Prob. 8AYLOCh. 17.3 - Prob. 9AYLOCh. 17.3 - Hormones produced by the following tissues and...Ch. 17.4 - What are the three chemical classes of hormones?...Ch. 17.4 - Prob. 18BYGOCh. 17.4 - Prob. 19BYGOCh. 17.4 - Prob. 20BYGOCh. 17.4 - Prob. 21BYGOCh. 17.4 - Prob. 1AYLOCh. 17.4 - Prob. 2AYLOCh. 17.4 - Prob. 3AYLOCh. 17.4 - Prob. 4AYLOCh. 17.4 - The Types of stimuli that elicit hormone...Ch. 17.4 - Thyroid hormone synthesis and secretionCh. 17.4 - Prob. 7AYLOCh. 17.4 - Prob. 8AYLOCh. 17.4 - Which hormones require second messengers to...Ch. 17.4 - How signal amplification enables small amounts of...Ch. 17.4 - How target cells modulate their hormone...Ch. 17.4 - Three kinds of interactions that can occur when...Ch. 17.4 - Prob. 13AYLOCh. 17.5 - Define stress from the standpoint of...Ch. 17.5 - Describe the stages of the general adaptation...Ch. 17.5 - Prob. 24BYGOCh. 17.5 - Prob. 1AYLOCh. 17.5 - Prob. 2AYLOCh. 17.5 - The three stages of the stress response; the...Ch. 17.6 - Prob. 25BYGOCh. 17.6 - Prob. 26BYGOCh. 17.6 - Prob. 27BYGOCh. 17.6 - Paracrine and autocrine secretions, examples, and...Ch. 17.6 - The general structure and metabolic precursor of...Ch. 17.6 - Prob. 3AYLOCh. 17.6 - Prob. 4AYLOCh. 17.6 - Prob. 5AYLOCh. 17.7 - Prob. 28BYGOCh. 17.7 - Prob. 29BYGOCh. 17.7 - Prob. 30BYGOCh. 17.7 - Prob. 1AYLOCh. 17.7 - Myxedema, endemic goiter, and toxic goiterCh. 17.7 - Effects of hypo- and hyperparathyroidismCh. 17.7 - Cushing syndrome and adrenogenital syndromeCh. 17.7 - Prob. 5AYLOCh. 17.7 - Prob. 6AYLOCh. 17.7 - Prob. 7AYLOCh. 17.7 - Consequences of inadequately treated DM and why...Ch. 17 - CRH secretion would not raise the blood...Ch. 17 - Prob. 2TYRCh. 17 - Prob. 3TYRCh. 17 - Prob. 4TYRCh. 17 - Prob. 5TYRCh. 17 - Prob. 6TYRCh. 17 - Prob. 7TYRCh. 17 - Prob. 8TYRCh. 17 - Prob. 9TYRCh. 17 - Prostaglandins are derived from a. phospholipase....Ch. 17 - Prob. 11TYRCh. 17 - Prob. 12TYRCh. 17 - Growth hormone hypersecretion in adulthood causes...Ch. 17 - Prob. 14TYRCh. 17 - Prob. 15TYRCh. 17 - Prob. 16TYRCh. 17 - Target cells can reduce pituitary secretion by a...Ch. 17 - Prob. 18TYRCh. 17 - Prob. 19TYRCh. 17 - ______ is a process in which a cell increases its...Ch. 17 - adeno-Ch. 17 - Prob. 2BYMVCh. 17 - Prob. 3BYMVCh. 17 - Prob. 4BYMVCh. 17 - Prob. 5BYMVCh. 17 - Prob. 6BYMVCh. 17 - Prob. 7BYMVCh. 17 - Prob. 8BYMVCh. 17 - Prob. 9BYMVCh. 17 - Prob. 10BYMVCh. 17 - Castration would lower a mans blood gonadotropin...Ch. 17 - Prob. 2WWTSCh. 17 - Prob. 3WWTSCh. 17 - Prob. 4WWTSCh. 17 - Prob. 5WWTSCh. 17 - The great majority of cases of diabetes mellitus...Ch. 17 - Prob. 7WWTSCh. 17 - A deficiency of dietary iodine would lead to...Ch. 17 - Prob. 9WWTSCh. 17 - Prob. 10WWTSCh. 17 - Prob. 1TYCCh. 17 - Suppose you were browsing in a health-food store...Ch. 17 - Prob. 3TYCCh. 17 - Prob. 4TYCCh. 17 - A young man is involved in a motorcycle accident...
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