The role of Rh factor in hemolytic disease development and how this disease is prevented in newborns. Concept introduction: Rh factor is a type of antigen present in the blood (known as the D antigen). This antigen is present in 85% of the total population. Rh blood type is a result of combination of two alleles. A dominant allele which codes for the factor and a recessive allele which does not code for such factor. If a person inherits even a single Rh gene, then the blood group will be Rh-positive (Rh+). Only persons inheriting both recessive genes are Rh-negative (Rh−).

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Alleles at the P locus control seed color. Plants which are pp have white seeds, white flowers and no pigment in vegetative parts. Plants which are P_ have black seeds, purple flowers and may have varying degrees of pigment on stems and leaves. Seed color can be assessed, visually, based on if the seed is white or not white A gene for mold resistance has been reported and we want to determine its inheritance and whether it is linked to P. For the purposes of this exercise, we will assume that resistance is controlled by a single locus M, and M_ plants are resistant and mm plants are susceptible. Resistance can be measured, under greenhouse conditions, 2 weeks after planting, by injecting each seedling with a spore suspension. After two weeks, the seedlings can be rated as resistant or susceptible, based on whether or not tissue is actively sporulating. For this exercise we will use seed and data from the F10 generation of a recombinant inbred population produced using single seed…

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Question

Chapter 16.3, Problem 11AYP

Summary Introduction

To determine:

The role of Rh factor in hemolytic disease development and how this disease is prevented in newborns.

Concept introduction:

Rh factor is a type of antigen present in the blood (known as the D antigen). This antigen is present in 85% of the total population. Rh blood type is a result of combination of two alleles. A dominant allele which codes for the factor and a recessive allele which does not code for such factor. If a person inherits even a single Rh gene, then the blood group will be Rh-positive (Rh+). Only persons inheriting both recessive genes are Rh-negative (Rh−).

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