Chapter 16, Problem 63E

One of the important reactions in the biochemical pathway glycolysis is the reaction of glucose-6-phosphate (G6P) to form fructose-6-phosphate (F6P):

$\text{G6P}\rightleftharpoons \text{F}6\text{P}$ $\Delta G_{298}^{°}=1.7\text{kJ}$

(a) Is the reaction spontaneous or nonspontaneous under standard thermodynamic conditions?.

(b) Standard thermodynamic conditions imply the concentrations of G6P and F6P to be 1 M, however, in a typical cell, they are not even Close to these values. Calculate △G when the concentrations of G6P and F6P are 120 $\text{μ}$M and 28 $\text{μ}$ M respectively, and discuss the spontaneity of the forward reaction under these conditions. Assume the temperature is 37 °C.