Human Physiology
15th Edition
ISBN: 9781259864629
Author: Fox, Stuart Ira
Publisher: Mcgraw-hill Education,
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Chapter 16, Problem 43RA
Refer to figure 16.19 and calculate the
Air saturated with water vapor at a pressure of 2.5 atmospheres
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 16 Solutions
Human Physiology
Ch. 16 - Describe the structures involved in gas exchange...Ch. 16 - Prob. 1bCPCh. 16 - Describe how each lung is compartmentalized by the...Ch. 16 - Describe the changes in the intrapulmonary and...Ch. 16 - Explain how the compliance and elasticity of the...Ch. 16 - Describe pulmonary surfactant and discuss its...Ch. 16 - Describe the actions of the diaphragm and external...Ch. 16 - Explain how forced inspiration and forced...Ch. 16 - Define the terms tidal volume and vital capacity....Ch. 16 - How are the vital capacity and the forced...
Ch. 16 - Explain how the of air is calculated and how this...Ch. 16 - Explain how blood measurements are taken, and...Ch. 16 - Explain how the arterial and the oxygen content...Ch. 16 - Describe the ventilation/perfusion ratios of the...Ch. 16 - Explain how decompression sickness is produced in...Ch. 16 - Describe the roles of centers in the brain stem...Ch. 16 - Describe the effects of voluntary hyperventilation...Ch. 16 - Using a flowchart to show a negative feedback...Ch. 16 - Prob. 10bCPCh. 16 - Prob. 10cCPCh. 16 - Use a graph to illustrate the effects of Po2 on...Ch. 16 - Draw an oxyhemoglobin dissociation curve and label...Ch. 16 - Prob. 12aCPCh. 16 - Prob. 12bCPCh. 16 - List the ways in which carbon dioxide is carried...Ch. 16 - Where in the body does the chloride shift occur?...Ch. 16 - Where in the body does a reverse chloride shift...Ch. 16 - Using equations, show how carbonic acid and...Ch. 16 - Prob. 15aCPCh. 16 - Prob. 15bCPCh. 16 - Prob. 15cCPCh. 16 - Prob. 15dCPCh. 16 - Explain why a person with ketoacidosis...Ch. 16 - Prob. 16aCPCh. 16 - Explain why endurance-trained athletes have a...Ch. 16 - Prob. 17CPCh. 16 - Prob. 1RACh. 16 - Prob. 2RACh. 16 - The maximum amount of air that can be expired...Ch. 16 - Prob. 4RACh. 16 - Prob. 5RACh. 16 - Which of these would be most affected by a...Ch. 16 - Prob. 7RACh. 16 - Prob. 8RACh. 16 - The affinity of hemoglobin for oxygen is decreased...Ch. 16 - Prob. 10RACh. 16 - The bicarbonate concentration or the blood would...Ch. 16 - Prob. 12RACh. 16 - Prob. 13RACh. 16 - Which of these occur(s) during hypoxemia?...Ch. 16 - During exercise, which of these statements is...Ch. 16 - All of the following can bond with hemoglobin...Ch. 16 - Prob. 17RACh. 16 - The hypoxic ventilatory response occurs when low...Ch. 16 - Using a flow diagram to show cause and effect,...Ch. 16 - Radiographic (x-ray) pictures show that the rib...Ch. 16 - Explain, using a flowchart, how a rise in blood ...Ch. 16 - Explain why a person with ketoacidosis may...Ch. 16 - Prob. 23RACh. 16 - Explain how measurements of blood Pco2,...Ch. 16 - Describe the changes in ventilation that occur...Ch. 16 - Prob. 26RACh. 16 - Describe how ventilation changes when a person...Ch. 16 - Explain the physiological changes in the blood's...Ch. 16 - Compare asthma and emphysema in terms of their...Ch. 16 - Explain the mechanisms involved in quiet...Ch. 16 - Describe the formation, composition, and function...Ch. 16 - Prob. 32RACh. 16 - The nature of the sounds produced by percussion...Ch. 16 - Explain why the fast breath of a healthy neonate...Ch. 16 - Prob. 35RACh. 16 - Carbon monoxide poisoning from smoke inhalation...Ch. 16 - Prob. 37RACh. 16 - Explain how a subatmospheric intrapleural pressure...Ch. 16 - Prob. 39RACh. 16 - You cannot affect the oxygen delivery to your...Ch. 16 - Refer to figure 16.19 and calculate the Po2 of the...Ch. 16 - Refer to figure 16.19 and calculate the of the...Ch. 16 - Refer to figure 16.19 and calculate the Po2 of the...Ch. 16 - Use figure 16.34 to answer the following...Ch. 16 - Prob. 45RACh. 16 - Use figure 16.34 to answer the following...Ch. 16 - Prob. 47RA
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