Anatomy and Physiology by OpenStax
17th Edition
ISBN: 9781506698021
Author: J. Gordon Betts;Dean H. Kruse;Kelly A. Young;Peter DeSaix;Brandon Poe;Oksana Korol;James A. Wise;Eddie Johnson;Jody E. Johnson;Mark Womble
Publisher: XANEDU PUBLISHING
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Textbook Question
Chapter 16, Problem 23RQ
Which of the following nerves controls movements of the neck?
- oculomotor
- vestibulocochlear
- spinal accessory
- hypoglossal
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 16 Solutions
Anatomy and Physiology by OpenStax
Ch. 16 - Watch this video...Ch. 16 - Watch this video...Ch. 16 - Read this article...Ch. 16 - Watch the video...Ch. 16 - Watch this short video...Ch. 16 - Watch this video...Ch. 16 - Watch this video...Ch. 16 - Watch this short video...Ch. 16 - Which major section of the neurological exam is...Ch. 16 - What function would most likely be affected by a...
Ch. 16 - Which major section of the neurological exam...Ch. 16 - Memory, emotional, language, and sensorimotor...Ch. 16 - Where is language function localized in the...Ch. 16 - Which of the following could be elements of cyto...Ch. 16 - Which of the following could be a multimodal...Ch. 16 - Which is an example of episodic memory? how to...Ch. 16 - Which type of aphasia is more like hearing a...Ch. 16 - What region of the cerebral cortex is associated...Ch. 16 - Without olfactory sensation to complement...Ch. 16 - Which of the following cranial nerves is not part...Ch. 16 - Which nerve is responsible for controlling the...Ch. 16 - Which nerve is responsible for taste, as well as...Ch. 16 - Which of the following nerves controls movements...Ch. 16 - Which of the following is not part of the...Ch. 16 - Which subtest is directed at proprioceptive...Ch. 16 - What term describes the inability to lift the aim...Ch. 16 - Which type of reflex is the jaw-jerk reflex that...Ch. 16 - Which of the following is a feature of both...Ch. 16 - Which white matter structure carries information...Ch. 16 - Which region of the cerebellum receives...Ch. 16 - Which of the following tests cerebellar function...Ch. 16 - Which of the following is not a cause of...Ch. 16 - Which of the following functions cannot be...Ch. 16 - Why is a rapid assessment of neurological function...Ch. 16 - How is the diagnostic category of TIA different...Ch. 16 - A patients performance of the majority of the...Ch. 16 - A patient responds to the question What is your...Ch. 16 - As a person ages, their ability to focus on near...Ch. 16 - When a patient flexes their neck, the head tips to...Ch. 16 - The location of somatosensation is based on the...Ch. 16 - Why are upper motor neuron lesions characterized...Ch. 16 - Learning to ride a bike is a motor function...Ch. 16 - Alcohol intoxication can produce slurred speech....
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