EBK BIOCHEMISTRY
6th Edition
ISBN: 9781337431200
Author: GRISHAM
Publisher: CENGAGE LEARNING - CONSIGNMENT
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Chapter 16, Problem 22P
Interpretation Introduction
To Explain:
Function of switch 1 of active model for K1F1A kinesin protein should be identified. Why K1F1A cannot move cargo when switch 1 is bound to AMPPNP should be explained.
Introduction:
A kinesin is a protein which acts as molecular motor in eukaryotic cells. Using the free energy by ATP hydrolysis kinesins move along microtubules. The active movement of kinesins involve in several cellular functions such as mitosis, meiosis and axonal transport. K1F1A is a member of kinesin family.
A non-hydrolysable analogue of ATP is AMP-PNP. It enhances the interaction between membranous organelles and microtubules and inhibits axonal transport.
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9. Which one of the compounds below is the major organic product obtained from
the following reaction sequence, starting with ethyl acetoacetate?
요요.
1. NaOCH2CH3
CH3CH2OH
1. NaOH, H₂O
2. H3O+
3. A
OCH2CH3
2.
ethyl acetoacetate
ii
A
3. H3O+
OH
B
C
D
E
7. Only one of the following ketones cannot be made via an acetoacetic ester
synthesis. Which one is it?
Ph
کہ
A
B
C
D
E
2. Which one is the
major organic
product obtained
from the following
reaction sequence?
HO
A
OH
1. NaOEt, EtOH
1. LiAlH4
EtO
OEt
2. H3O+
2. H3O+
OH
B
OH
OH
C
-OH
HO
-OH
OH
D
E
.CO₂Et
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