Biochemistry
6th Edition
ISBN: 9781337359573
Author: Reginald H. Garrett; Charles M. Grisham
Publisher: Cengage Learning US
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Chapter 16, Problem 22P
Interpretation Introduction
To Explain:
Function of switch 1 of active model for K1F1A kinesin protein should be identified. Why K1F1A cannot move cargo when switch 1 is bound to AMPPNP should be explained.
Introduction:
A kinesin is a protein which acts as molecular motor in eukaryotic cells. Using the free energy by ATP hydrolysis kinesins move along microtubules. The active movement of kinesins involve in several cellular functions such as mitosis, meiosis and axonal transport. K1F1A is a member of kinesin family.
A non-hydrolysable analogue of ATP is AMP-PNP. It enhances the interaction between membranous organelles and microtubules and inhibits axonal transport.
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