Chapter 16, Problem 16.39P

(a)

Interpretation Introduction

Interpretation:

Show how the given drug can be synthesized by reductive amination of an appropriate aldehyde or ketone and amine.

Concept Introduction:

Treatment of an aldehyde or ketone with ammonia or an amine in the presence of a reducing agent (like ${\text{NaBH}}_{\text{4}}\text{,}{\text{H}}_{\text{2}}\text{/}\text{Ni}$) is known as reductive amination.

Example:

(b)

Interpretation Introduction

Interpretation:

Show how the given drug can be synthesized by reductive amination of an appropriate aldehyde or ketone and amine.

Concept Introduction:

Treatment of an aldehyde or ketone with ammonia or an amine in the presence of a reducing agent (like ${\text{NaBH}}_{\text{4}}\text{,}{\text{H}}_{\text{2}}\text{/}\text{Ni}$) is known as reductive amination.

Example: