CUSTOM BIOLOGY
CUSTOM BIOLOGY
19th Edition
ISBN: 9781323945490
Author: Urry
Publisher: Pearson Custom Publishing
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Chapter 16, Problem 12TYU
Summary Introduction

To explain: The structure of DNA correlates with its role in the molecular basis of inheritance.

Theme introduction:

The transmission of traits to the next generations is known as heredity. The heritable genetic information is in the form of DNA. The DNA structure and function are linked and, these are based on the base pair composition and their arrangement.

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
You implant an FGF10-coated bead into the anterior flank of a chicken embryo, directly below the level of the wing bud. What is the phenotype of the resulting ectopic limb?  Briefly describe the expected expression domains of 1) Shh, 2) Tbx4, and 3) Tbx5 in the resulting ectopic limb bud.
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DNA vs RNA (Updated); Author: Amoeba Sisters;https://www.youtube.com/watch?v=JQByjprj_mA;License: Standard youtube license