Foundations in Microbiology
10th Edition
ISBN: 9781259705212
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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6. Sickle cell anemia is a genetic disease resulting from a single amino acid substitution
(glutamate to valine in the sixth position, or E6V) on the surface of the hemoglobin B
chain. This mutation causes hemoglobin to polymerize into strands in the deoxygenated
state, leading to the erythrocytes forming a sickled shape.
a. Speculate as to why the mutation leads to the polymerization of hemoglobin. In
the structure below, the red circles show the approximate location of the
mutation.
a subunits
B subunits.
b. Given that the binding of oxygen to hemoglobin cause the structure of the protein
to change, hypothesize why the E6V mutation only causes polymerization in the
deoxygenated state.
options to match
a. same linkage group, unlinked
b. different linkage group, unlinked
c. different linkage group, linked
d. same linkage group, linked
Can you check if A is correct and please help answer the following questions?
Chapter 15 Solutions
Foundations in Microbiology
Ch. 15.1 - Summarize the general features of adaptive,...Ch. 15.1 - Prob. 2ELOCh. 15.1 - Prob. 3ELOCh. 15.1 - Prob. 4ELOCh. 15.1 - Describe the major events in the origin of...Ch. 15.1 - Describe the development of antigen receptors on...Ch. 15.1 - Prob. 7ELOCh. 15.1 - Discuss what is meant by immunocompetence, immune...Ch. 15.1 - What function do receptors play in specific immune...Ch. 15.1 - Prob. 3CYP
Ch. 15.1 - Explain the clonal selection theory of receptor...Ch. 15.1 - Why must the body develop tolerance to seit?Ch. 15.1 - Prob. 6CYPCh. 15.1 - What is happening during lymphocyte maturation?Ch. 15.1 - Prob. 8CYPCh. 15.2 - Explain the characteristics of antigens, the...Ch. 15.2 - Discuss the main categories of antigens, based on...Ch. 15.2 - What are antigens, immunogens, and epitopes, and...Ch. 15.2 - How do foreignness, size, and complexity...Ch. 15.2 - Compare five unique types of antigens, and explain...Ch. 15.3 - Describe the cooperative interactions between...Ch. 15.3 - Discuss the actions of interleukins in the early...Ch. 15.3 - Prob. 12ELOCh. 15.3 - Prob. 13ELOCh. 15.3 - Prob. 14ELOCh. 15.3 - Prob. 15ELOCh. 15.3 - Prob. 12CYPCh. 15.3 - Prob. 13CYPCh. 15.3 - Prob. 14CYPCh. 15.3 - Prob. 15CYPCh. 15.3 - Prob. 16CYPCh. 15.3 - Prob. 17CYPCh. 15.3 - Prob. 18CYPCh. 15.3 - Discuss how superantigens are different from other...Ch. 15.4 - Prob. 16ELOCh. 15.4 - Prob. 17ELOCh. 15.4 - Prob. 18ELOCh. 15.4 - Prob. 19ELOCh. 15.4 - Prob. 20CYPCh. 15.4 - What are the functions of plasma cells, clonal...Ch. 15.4 - Prob. 22CYPCh. 15.4 - Prob. 23CYPCh. 15.4 - Describe the attachment of antibodies to antigens....Ch. 15.4 - Prob. 25CYPCh. 15.4 - Prob. 26CYPCh. 15.4 - What causes the latent period and the anamnestic...Ch. 15.5 - Prob. 20ELOCh. 15.5 - Differentiate between natural and artificial...Ch. 15.5 - Expand on the four combinations of the defining...Ch. 15.5 - Prob. 28CYPCh. 15.5 - Name at least two major ways in which natural and...Ch. 15.5 - Prob. 30CYPCh. 15.6 - Explain the purposes of immunotherapy and...Ch. 15.6 - Describe the sources and uses of artificial...Ch. 15.6 - Discuss which factors are involved in vaccine...Ch. 15.6 - Identify the major categories of vaccine antigens,...Ch. 15.6 - Prob. 27ELOCh. 15.6 - Describe the preparation of killed vaccines; live,...Ch. 15.6 - Prob. 32CYPCh. 15.6 - Prob. 33CYPCh. 15.6 - Prob. 34CYPCh. 15.L1 - Which of these characteristics is not a major...Ch. 15.L1 - Prob. 2MCQCh. 15.L1 - In humans, B cells mature in the _____________ and...Ch. 15.L1 - Small, simple molecules are_________antigens. a....Ch. 15.L1 - Which type of cell actually secretes antibodies?...Ch. 15.L1 - CD4 cells are ________ cells and CD8 cells are...Ch. 15.L1 - Prob. 7MCQCh. 15.L1 - Prob. 8MCQCh. 15.L1 - Prob. 9MCQCh. 15.L1 - Prob. 10MCQCh. 15.L1 - Prob. 11MCQCh. 15.L1 - Prob. 12MCQCh. 15.L1 - Prob. 13MCQCh. 15.L1 - A living microbe with reduced virulence that is...Ch. 15.L1 - A vaccine that contains parts of viruses is called...Ch. 15.L1 - Prob. 16MCQCh. 15.L1 - Prob. 17MCQCh. 15.L1 - Prob. 18MCQCh. 15.L1 - Prob. 19MCQCh. 15.L1 - Prob. 20MCQCh. 15.L1 - Prob. 1CSRCh. 15.L1 - Prob. 2CSRCh. 15.L1 - Prob. 3CSRCh. 15.L1 - Using words and arrows, complete a flow outline of...Ch. 15.L1 - Prob. 2WCCh. 15.L1 - Prob. 3WCCh. 15.L1 - Prob. 4WCCh. 15.L1 - Prob. 5WCCh. 15.L1 - Combine information on the functions of different...Ch. 15.L2 - Prob. 1CTCh. 15.L2 - Prob. 2CTCh. 15.L2 - Double-stranded DNA is a large, complex molecule,...Ch. 15.L2 - Prob. 4CTCh. 15.L2 - Describe the relationship between an antitoxin, a...Ch. 15.L2 - Prob. 6CTCh. 15.L2 - Prob. 7CTCh. 15.L2 - Prob. 8CTCh. 15.L2 - Prob. 9CTCh. 15.L2 - Prob. 1VCCh. 15.L2 - Examine figure 6.6c and determine which components...
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