EBK HUMAN PHYSIOLOGY
8th Edition
ISBN: 9780134704227
Author: Silverthorn
Publisher: YUZU
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Chapter 15, Problem 35RQ
Summary Introduction
To calculate: The mean arterial pressure and pulse pressure of an individual having a blood pressure of 115/73.
Introduction: Blood pressure is the force exerted by the blood on the walls of the blood vessels. The blood pressure is recorded in two components, systolic pressure and diastolic pressure.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 15 Solutions
EBK HUMAN PHYSIOLOGY
Ch. 15.2 - Would you expect to find valves in the veins...Ch. 15.2 - Prob. 2CCCh. 15.2 - Who has the higher pulse pressure, someone with...Ch. 15.2 - The formula given for calculating MAP applies to a...Ch. 15.2 - Prob. 5CCCh. 15.3 - Resistance to blood flow is determined primarily...Ch. 15.3 - Prob. 7CCCh. 15.3 - Prob. 8CCCh. 15.3 - Skeletal muscle arterioles have both - and...Ch. 15.4 - Prob. 10CC
Ch. 15.4 - Prob. 11CCCh. 15.5 - Prob. 12CCCh. 15.5 - In the classic movie Jurassic Park, Dr. Ian...Ch. 15.6 - A man with liver disease loses the ability to...Ch. 15.6 - Prob. 15CCCh. 15.7 - Prob. 16CCCh. 15.7 - Malnourished children who have inadequate protein...Ch. 15 - Prob. 1RQCh. 15 - Prob. 2RQCh. 15 - Prob. 3RQCh. 15 - Prob. 4RQCh. 15 - Prob. 5RQCh. 15 - Prob. 6RQCh. 15 - List the factors that aid venous return to the...Ch. 15 - Prob. 8RQCh. 15 - Prob. 9RQCh. 15 - Prob. 10RQCh. 15 - Prob. 11RQCh. 15 - Most systemic arterioles are innervated by the...Ch. 15 - Match each event in the left column with all...Ch. 15 - Which organs receive more than two-thirds of the...Ch. 15 - By looking at the density of capillaries in a...Ch. 15 - Prob. 16RQCh. 15 - Prob. 17RQCh. 15 - Define edema. List some ways in which it can...Ch. 15 - Prob. 19RQCh. 15 - Prob. 20RQCh. 15 - Calcium channel blockers prevent Ca2+ movement...Ch. 15 - Prob. 22RQCh. 15 - Prob. 23RQCh. 15 - Define myogenic autoregulation. What mechanisms...Ch. 15 - Left ventricular failure may be accompanied by...Ch. 15 - Robert is a 52-year-old nonsmoker. He weighs 180...Ch. 15 - The following figure is a schematic representation...Ch. 15 - Prob. 28RQCh. 15 - Draw a reflex map that explains Anthonys vasovagal...Ch. 15 - Prob. 30RQCh. 15 - Prob. 31RQCh. 15 - Prob. 32RQCh. 15 - Prob. 33RQCh. 15 - Prob. 34RQCh. 15 - Prob. 35RQCh. 15 - Prob. 36RQCh. 15 - Prob. 37RQCh. 15 - Prob. 38RQCh. 15 - Prob. 39RQ
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