The effects of large doses of dopamine on a patient. Introduction: Dopamine is a catecholamine, which plays a significant part in the human body. It acts as a neurotransmitter in the brain. It acts as a paracrine messenger outside the central nervous system as it is locally produced and shows its effects in the neighboring cells.

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engineered constructs that consist of hollow fibers are acting as synthetic capillaries, around which cells have been loaded. The cellular space around a single fiber can be modeled as if it were a Krogh tissue cylinder. Each fiber has an outside “capillary” radius of 100 µm and the “tissue” radius can be taken as 200 µm. The following values apply to the device:R0 = 20 µM/secaO2 = 1.35 µM/mmHgDO2,T = 1.67 x 10-5 cm2/secPO2,m = 4 x 10-3 cm/secInstead of blood inside the fibers, the oxygen transport and tissue consumption are being investigated by usingan aqueous solution saturated with pure oxygen. As a result, there is no mass transfer resistance in the synthetic“capillary”, only that due to the membrane itself. Rather than accounting for pO2 variations along the length ofthe fiber, use an average value in the “capillary” of 130 mmHg.Is the tissue fully oxygenated?

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Chapter 15, Problem 1CAQ1

Summary Introduction

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The effects of large doses of dopamine on a patient.

Introduction:

Dopamine is a catecholamine, which plays a significant part in the human body. It acts as a neurotransmitter in the brain. It acts as a paracrine messenger outside the central nervous system as it is locally produced and shows its effects in the neighboring cells.

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