Concept explainers
(a)
To determine: The effects on the
Introduction:
Researchers have manipulated mouse genes so that a single gene in a particular tissue either produces an active protein or produces an inactive protein. The inactivation of protein (knockout) or production of active protein should be in continuation.
(b)
To determine: The effects on metabolism with genetic change such as knockout of hexokinase IV in the liver.
Introduction:
Metabolism is the “sum of the
(c)
To determine: The effects on metabolism with genetic change such as knockout of FBPase-2 in the liver.
Introduction:
Researchers have manipulated mouse genes so that a single gene in a particular tissue either produces an active protein or produces an inactive protein. The inactivation of protein (knockout) or production of active protein should be in continuation.
(d)
To determine: The effects on metabolism with genetic change such as constitutively active FBPase-2 in the liver.
Introduction:
Metabolism is the “sum of the chemical reactions that occur within the body”. It controls the chemical reactions and cellular structure in an organism. Metabolic energy is stored in the form of chemical bonds of ATP.
(e)
To determine: The effects on metabolism with genetic change such as constitutively active AMPK in muscle.
Introduction:
Metabolism is the “sum of the chemical reactions that occur within the body”. There are two categories of metabolism: catabolism and anabolism. Breakdown of molecules in the body to obtain energy is catabolism while synthesis of compounds required by the body using energy is known as anabolism.
(f)
To determine: The effects on metabolism with genetic change such as constitutively active ChREBP in the liver.
Introduction:
Metabolism is the “sum of the chemical reactions that occur within the body”. It controls the chemical reactions and cellular structure in an organism. Metabolic energy is stored in the form of chemical bonds of ATP.

Want to see the full answer?
Check out a sample textbook solution
Chapter 15 Solutions
Lehninger Principles of Biochemistry (Instructor's)
- I am a Biochemistry student and I am confused on how to analyze FRAP Analysis using Excel Spread Sheets. The following spread sheet has my 0 minute data listed at top and the 4 minute data listed on the bottom. Sheet: https://mnscu-my.sharepoint.com/:x:/g/personal/vi2163ss_go_minnstate_edu/EXjrCizWiXRPmpittqZA12IB8EkB5eE8iaRqj_iun-IAtg?rtime=Wo9zPHFY3Ug The formula for FRAP Analysis is: FRAP value = A (4 min sample) - A (0 min sample) over A (4 min 30 uM ascorbic acid) - A (0 min 30 uM ascorbic acid) multiplied by 30 uM and the dilution factor of 1/10arrow_forwardHO Fill in the missing boxes. ON 800 NO NO Glucose ATP NADH Hexokinase 1,3-Bisphosphoglycerate Mg2+ ADP NAD+, Pi Phosphoglucose Isomerase Glucose-6-Phosphate ON 沁 Glyceraldehyde-3-Phosphate HO حلمة ADP ADP Phospho Mg2+ glycerate Dihydroxyacetone Phosphate ATP kinase ATP Phosphoglycerate 3-phosphoglycerate Mutase H₁₂O Fructose-6-Phosphate ATP Mg2+ ADP Fructose-1,6-Bisphosphate 2-phosphoglycerate H₂O Phosphoenolpyruvate ADP Mg2+ ATP Pyruvatearrow_forwardIn a diffraction experiment of a native crystal, intensity of reflection (-1 0 6) is equivalent to the intensity of reflection (1 0 -6). true or false?arrow_forward
- in an x-ray diffraction experiment, moving the detector farther away from the crystal will allow collection of reflection of reflections with high Miller indices. true or false?arrow_forwardShow the mechanism for the acid-catalyzed formation of an [α-1,6] glycosidic linkagebetween two molecules of α-D-glucopyranose.arrow_forwardLabel the following polysaccharide derivatives as reducing or nonreducing. a. C. b. HO CH₂OH CH2OH OH OH OH OH OH HOCH₂ OH OH OH HOCH₂ HO HO HO OH OH ΙΟ CH₂OH OH OH "OH OHarrow_forward
- For a red blood cell (erythrocyte) undergoing active glycolysis, briefly explain how increases in concentration of the following factors are likely to affect glycolytic flux. a. ATP b. AMP c. F-1,6-BP d. F-2,6-BP e. Citrate f. Glucose-6-phosphatearrow_forwardThe ∆G°’ for hydrolysis of phosphoenol pyruvate is -62.2 kJ/mol. The standard freeenergy of ATP hydrolysis is -30.5 kJ/mol. A. What is the standard free energy and K eq of the spontaneous reaction betweenADP/ATP and phosphoenol pyruvate. B. Repeat A for F-1,6-BP (∆G°’=-16.7 kJ/mol) and 1,3-BPG (∆G°’=-49.6 kJ/mol)hydrolysis. C. If the ATP and ADP concentrations are 8mM and 1mM respectively, what would bethe ratio of pyruvate/phosphoenolpyruvate at equilibrium?arrow_forwardAnswerarrow_forward
- 13. Which one is the major organic product of the following sequence of reactions? A OH (CH3)2CHCH2COOH SOCI2 CH3OH 1. CH3MgBr 2. H₂O, H+ B C D OH E OHarrow_forward14. Which one is the major organic product of the following sequence of reactions? (CH3)2CH-COCI CH3OH 1. DIBALH, -78°C 1. PhCH2MgBr ? 2. H2O, HCI 2. H2O, HCI OH OMe A Ph B Ph OH Ph C OMe Ph D E OH .Pharrow_forward6. Which one is the major organic product obtained from the following reaction? CO₂Me 1. LiAlH4 2. H₂O CH₂OH CH₂OCH3 5555 HO A B HO C HO D CH₂OH E ?arrow_forward
- BiochemistryBiochemistryISBN:9781319114671Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.Publisher:W. H. FreemanLehninger Principles of BiochemistryBiochemistryISBN:9781464126116Author:David L. Nelson, Michael M. CoxPublisher:W. H. FreemanFundamentals of Biochemistry: Life at the Molecul...BiochemistryISBN:9781118918401Author:Donald Voet, Judith G. Voet, Charlotte W. PrattPublisher:WILEY
- BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage LearningBiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage LearningFundamentals of General, Organic, and Biological ...BiochemistryISBN:9780134015187Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. PetersonPublisher:PEARSON





