Genetics: From Genes to Genomes, 5th edition
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 15, Problem 16P
Summary Introduction

a.

To determine:

The type of suppressor mutations that are expected to arise by using this screen as compared with a screen used for only Lac+.

Introduction:

The crp gene encodes the positive regulator of CRP. The cells that contain missense mutation in the crp gene include Lac-, Mal-, and Gal-. The cells containing suppressors of the crp mutation behave as if they are crp+. To find these cells, the cells were screened to find those containing Lac+ and Mal+.

Summary Introduction

b.

To determine:

The hypothesis that can be proposed based upon the given analysis.

Introduction:

The analysis revealed that all the suppressors that were isolated were found to be mutant in the gene for the α-subunit of RNA polymerase.

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Genetics: From Genes to Genomes, 5th edition

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