(a)
To explain: The effect on glycogen
Introduction:
Glycogen is a branched, large
(b)
To explain: The effect on glycogen metabolism due to loss of protein phosphatase inhibitor.
Introduction:
Glycogen is a branched, large polymer. It is composed of glucose residues. Glucose present in liver and skeletal muscle is stored as glycogen. In liver, synthesis and breakdown of glycogen is regulated by level of glucose in the blood that is required to meet the daily requirement of the organism.
(c)
To explain: The effect on glycogen metabolism due to overexpression of phosphorylase b kinase in liver.
Introduction:
Glycogen is a branched, large polymer. It is composed of glucose residues. Glucose present in liver and skeletal muscle is stored as glycogen. In liver, synthesis and breakdown of glycogen is regulated by level of glucose in the blood that is required to meet the daily requirement of the organism.
(d)
To explain: The effect on glycogen metabolism due to defective glucagon receptors in liver.
Introduction:
Glycogen is a branched, large polymer. It is composed of glucose residues. Glucose present in liver and skeletal muscle is stored as glycogen. In liver, synthesis and breakdown of glycogen is regulated by level of glucose in the blood that is required to meet the daily requirement of the organism.
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Chapter 15 Solutions
Loose-leaf Version for Lehninger Principles of Biochemistry 7E & SaplingPlus for Lehninger Principles of Biochemistry 7E (Six-Month Access)
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- Sodium fluoroacetate (FCH 2CO2Na) is a very toxic molecule that is used as rodentpoison. It is converted enzymatically to fluoroacetyl-CoA and is utilized by citratesynthase to generate (2R,3S)-fluorocitrate. The release of this product is a potentinhibitor of the next enzyme in the TCA cycle. Show the mechanism for theproduction of fluorocitrate and explain how this molecule acts as a competitiveinhibitor. Predict the effect on the concentrations of TCA intermediates.arrow_forwardIndicate for the reactions below which type of enzyme and cofactor(s) (if any) wouldbe required to catalyze each reaction shown. 1) Fru-6-P + Ery-4-P <--> GAP + Sed-7-P2) Fru-6-P + Pi <--> Fru-1,6-BP + H2O3) GTP + ADP <--> GDP + ATP4) Sed-7-P + GAP <--> Rib-5-P + Xyl-5-P5) Oxaloacetate + GTP ---> PEP + GDP + CO 26) DHAP + Ery-4-P <--> Sed-1,7-BP + H 2O7) Pyruvate + ATP + HCO3- ---> Oxaloacetate + ADP + Piarrow_forwardTPP is also utilized in transketolase reactions in the PPP. Give a mechanism for theTPP-dependent reaction between Xylulose-5-phosphate and Ribose-5-Phosphate toyield Glyceraldehyde-3-phosphate and Sedoheptulose-7-Phosphate.arrow_forward
- What is the difference between a ‘synthetase’ and a ‘synthase’?arrow_forwardIn three separate experiments, pyruvate labeled with 13C at C-1, C-2, or C-3 is introduced to cells undergoing active metabolism. Trace the fate of each carbon through the TCA cycle and show when each of these carbons produces 13CO2.a. Glucose is similarly labeled at C-2 with 13C. During which reaction will this labeled carbon be released as 13CO2?arrow_forwardDraw the Krebs Cycle and show the entry points for the amino acids Alanine,Glutamic Acid, Asparagine, and Valine into the Krebs Cycle. How many rounds of Krebs will be required to waste all Carbons of Glutamic Acidas CO2?arrow_forward
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