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Chapter 15, Problem 14P

(a)

Summary Introduction

To explain: The effect on glycogen metabolism due to loss of the cAMP-binding site on the regulatory subunit of protein kinase A.

Introduction:

Glycogen is a branched, large polymer. It is composed of glucose residues. Glucose present in liver and skeletal muscle is stored as glycogen. In liver, synthesis and breakdown of glycogen is regulated by level of glucose in the blood that is required to meet the daily requirement of the organism.

(b)

Summary Introduction

To explain: The effect on glycogen metabolism due to loss of protein phosphatase inhibitor.

Introduction:

Glycogen is a branched, large polymer. It is composed of glucose residues. Glucose present in liver and skeletal muscle is stored as glycogen. In liver, synthesis and breakdown of glycogen is regulated by level of glucose in the blood that is required to meet the daily requirement of the organism.

(c)

Summary Introduction

To explain: The effect on glycogen metabolism due to overexpression of phosphorylase b kinase in liver.

Introduction:

Glycogen is a branched, large polymer. It is composed of glucose residues. Glucose present in liver and skeletal muscle is stored as glycogen. In liver, synthesis and breakdown of glycogen is regulated by level of glucose in the blood that is required to meet the daily requirement of the organism.

(d)

Summary Introduction

To explain: The effect on glycogen metabolism due to defective glucagon receptors in liver.

Introduction:

Glycogen is a branched, large polymer. It is composed of glucose residues. Glucose present in liver and skeletal muscle is stored as glycogen. In liver, synthesis and breakdown of glycogen is regulated by level of glucose in the blood that is required to meet the daily requirement of the organism.

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