Chapter 15, Problem 11CONQ

Summary Introduction

To review:

The effect of a particular drug that inhibits the protein kinase, on the following events:

A. The ability of the CREB (cyclic adenosine monophosphate (cAMP) response element binding)protein to bind to CREs(cAMP response elements).

B. The ability of extracellular hormones to enhance cAMP level.

C. The ability of the CREB protein to stimulate transcription.

D. The ability of the CREB protein to dimerize.

Introduction:

Protein kinase A is a significant enzyme in the mechanism of CREB proteinactivation. It is essentially activated by the elevated concentration of cAMP. It is responsible for the phosphorylation of CREB protein inside the nucleus.