Foundations in Microbiology
10th Edition
ISBN: 9781259705212
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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Chapter 14.L1, Problem 1WC
Use the lines on the figure to the right to locate and describe the eight components of the first line of defense.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 14 Solutions
Foundations in Microbiology
Ch. 14.1 - Summarize the characteristics of basic host...Ch. 14.1 - Differentiate between the three lines of defense,...Ch. 14.1 - Explain the nature of the different types of...Ch. 14.1 - Explain the functions of the three lines of...Ch. 14.1 - What is the difference between nonspecific host...Ch. 14.1 - Differentiate innate defenses and acquired...Ch. 14.1 - List four innate defensive responses present in...Ch. 14.2 - Prob. 4ELOCh. 14.2 - Describe several features of the recognition...Ch. 14.2 - Characterize pattern recognition receptors and...
Ch. 14.2 - Describe the microscopic anatomy of body...Ch. 14.2 - Prob. 8ELOCh. 14.2 - Prob. 9ELOCh. 14.2 - Prob. 10ELOCh. 14.2 - Prob. 11ELOCh. 14.2 - Prob. 5CYPCh. 14.2 - Prob. 6CYPCh. 14.2 - Prob. 7CYPCh. 14.2 - What are the main components of the...Ch. 14.2 - Prob. 9CYPCh. 14.2 - Prob. 10CYPCh. 14.2 - Prob. 11CYPCh. 14.2 - Prob. 12CYPCh. 14.2 - Describe the principal function of the two...Ch. 14.2 - What is Lymph, and how is it formed?Ch. 14.2 - Prob. 15CYPCh. 14.3 - Describe the main events in the inflammatory...Ch. 14.3 - Prob. 13ELOCh. 14.3 - Describe the mechanism behind fever, and explain...Ch. 14.3 - Describe the major events in the inflammatory...Ch. 14.3 - Of rubor, calor, dolor, and tumor, which are signs...Ch. 14.3 - Prob. 18CYPCh. 14.3 - Prob. 19CYPCh. 14.3 - Prob. 20CYPCh. 14.3 - Prob. 21CYPCh. 14.3 - Explain the processes of diapedesis and...Ch. 14.3 - Prob. 23CYPCh. 14.4 - Prob. 15ELOCh. 14.4 - Indicate the major stages of phagocytosis, and...Ch. 14.4 - Prob. 17ELOCh. 14.4 - Prob. 18ELOCh. 14.4 - Characterize the complement system, its origins,...Ch. 14.4 - Prob. 24CYPCh. 14.4 - What are the types of macrophages, and what are...Ch. 14.4 - Prob. 26CYPCh. 14.4 - Prob. 27CYPCh. 14.4 - Prob. 28CYPCh. 14.4 - Prob. 29CYPCh. 14.4 - Prob. 30CYPCh. 14.4 - Using figure 14.21 as a guide, give examples for...Ch. 14.L1 - An example/examples of a nonspecific chemical...Ch. 14.L1 - Prob. 2MCQCh. 14.L1 - Prob. 3MCQCh. 14.L1 - Prob. 4MCQCh. 14.L1 - What is included in GALT? a. thymus b. Peyer’s...Ch. 14.L1 - Prob. 6MCQCh. 14.L1 - Monocytes are ___________ leukocytes that develop...Ch. 14.L1 - Prob. 8MCQCh. 14.L1 - Toll-like receptors are proteins on ___________ a....Ch. 14.L1 - Prob. 10MCQCh. 14.L1 - __________ is an example of an inflammatory...Ch. 14.L1 - Prob. 12MCQCh. 14.L1 - _________ interferon, produced by T lymphocytes,...Ch. 14.L1 - In what process is tumor necrosis factor (TNF) not...Ch. 14.L1 - Which of the following substances is not produced...Ch. 14.L1 - Prob. 16MCQCh. 14.L1 - Prob. 1CSRCh. 14.L1 - Prob. 2CSRCh. 14.L1 - Prob. 3CSRCh. 14.L1 - Use the lines on the figure to the right to locate...Ch. 14.L1 - Prob. 2WCCh. 14.L1 - Prob. 3WCCh. 14.L1 - Prob. 4WCCh. 14.L1 - Prob. 5WCCh. 14.L1 - Prob. 6WCCh. 14.L1 - Prob. 7WCCh. 14.L1 - Prob. 8WCCh. 14.L1 - Prob. 9WCCh. 14.L1 - Prob. 10WCCh. 14.L2 - Suggest some reasons that there is so much...Ch. 14.L2 - Prob. 2CTCh. 14.L2 - Prob. 3CTCh. 14.L2 - Prob. 4CTCh. 14.L2 - An obsolete treatment for syphilis involved...Ch. 14.L2 - Patients with a history of tuberculosis often show...Ch. 14.L2 - Shigella, Mycobacterium, and numerous other...Ch. 14.L2 - Account for the several inflammatory symptoms that...Ch. 14.L2 - Prob. 9CTCh. 14.L2 - Prob. 10CTCh. 14.L2 - Prob. 1VC
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